Features altered | Resulting altered mechanism |
---|---|
Cholesterol level | Signalling molecule recruitment [135] |
Membrane fluidity | Protein interaction [54] |
Lipid raft functions | Early signalling/immune synapse formation [135] |
Calcium influx | Induction of T cell activation |
Phosphatase activity | Control of negative signalling |
PTK (Lck) activity | |
LAT phosphorylation | Activation of LAT-associated molecules |
MAP Kinase activation | |
Cytoskeleton rearrangement | Cell-cell contact/Immune synapse formation |
Translocation of transcription factors | Induction of gene expression |
CD28 expression | T cell costimulation/anti-apoptotic signals [58] |
KIR expression | Formation of an activation platform |
KLRG-1, CD57, PD-1 expression |