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Table 4 Naïve and memory T4 lymphocyte distribution at basal state (T 0 ) and after supplementation with 13-cis-retinoic acid (T 1 )

From: Neutrophils are immune cells preferentially targeted by retinoic acid in elderly subjects

 

Young adults

Elderly

 
 

T0

T1

T0

T1

ANOVA

CD4-CD45RO+

     

%

31.2 ± 1.74

29.36 ± 1.26

34.24 ± 1.81

35.88 ± 1.88

A

109/L

0.751 ± 0.074

0.582 ± 0.052

0.527 ± 0.042

0.785 ± O.235

-

CD4-CD45RA+

     

%

25.87 ± 1.70

24.32 ± 1.35

13.80 ± 1.92

15.18 ± 1.633

A

109/L

0.620 ± 0.064

0.468 ± 0.222

0.219 ± 0.036

0.309 ± 0.078

A

  1. X ± SEM; n = 20 subjects per group. Lymphocytes are expressed both as percentages of lymphocyte number and as absolute values. Two-way repeated-measures ANOVA was performed to discriminate among the effects of age (A; p < 0.05), nutritional treatment (N; p < 0.05) and their interaction (I; p < 0.05).
  2. As no significant interaction was found, comparison of marginal means was carried out, which indicated a significant effect of age on the absolute number (in 109/L) of CD4-CD45RA (young: 0.54 ± 0.04 vs elderly: 0.26 ± 0.04) and on percentage of CD4-CD45RA (young: 24.9 ± 1.1 vs elderly: 14.5 ± 1.3) and CD4-CD45RO (young: 30.5 ± 1.1: vs elderly: 35.1 ± 1.3).
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Immunity & Ageing

ISSN: 1742-4933

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