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Table 2 Genes differentially expressed in PMBC of Aged patients with Infectious diseases in Acute phase (AIA) patients (n = 39) versus healthy aged (HA) probands (n = 28).

From: Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases

Gene Symbol

Gene Name

Accession Number

AIA/HA ratio

Benjamini

BCL2

B-cell CLL/lymphoma 2

NM_000633.1

0.58

p < 0.001

CASP8

Caspase 8, apoptosis-related cysteine peptidase

X98172.1

0.66

p < 0.001

CCL5

Chemokine (C-C motif) ligand 5

NM_002985.1

0.71

p < 0.001

CD28

CD28 antigen (Tp44)

NM_006139.1

0.61

p < 0.005

CD69

CD69 antigen (p60, early T-cell activation antigen)

NM_001781.1

0.44

p < 0.001

DDIT3

DNA-damage-inducible transcript 3

S40706.1

0.76

p < 0.01

DNAJB1

DnaJ (Hsp40) homolog, subfamily B, member 1

D49547.1

0.76

p < 0.001

EGR3

Early growth response 3

NM_004430.1

0.42

p < 0.05

LCK

Lymphocyte-specific protein tyrosine kinase

NM_005356.2

0.58

p < 0.001

CLU

Clusterin

J02908.1

1.79

p < 0.001

CTSD

Cathepsin D (lysosomal aspartyl peptidase)

M11233.1

1.50

p < 0.001

CTSZ

Cathepsin Z

AF136273.1

1.33

p < 0.05

GPX1

Glutathione peroxidase 1

M21304.1

1.21

p < 0.05

HMOX1

Heme oxygenase (decycling) 1

NM_002133.1

1.57

p < 0.001

IL10RB

Interleukin 10 receptor, beta

NM_000628.3

1.39

p < 0.001

IL1R1

Interleukin 1 receptor, type I

NM_000877.2

1.48

p < 0.05

IL1R2

Interleukin 1 receptor, type II

U74649.1

2.34

p < 0.001

PRDX6

Peroxiredoxin 6

NM_004905.1

1.23

p < 0.005

PSMD1

Proteasome (prosome, macropain) 26 S subunit, non-ATPase, 1

NM_002807.1

1.24

p < 0.001

SERPINB2

Serpin peptidase inhibitor, clade B (ovalbumin), member 2

J02685.1

2.17

p < 0.005

SOD2

Superoxide dismutase 2, mitochondrial

NM_000636.1

1.53

p < 0.001

TIMP1

TIMP metallopeptidase inhibitor 1

NM_003254.1

1.71

p < 0.001

TIMP2

TIMP metallopeptidase inhibitor 2

NM_003255.2

1.59

p < 0.001

TNFRSF1A

Tumor necrosis factor receptor superfamily, member 1A

NM_001065.2

1.45

p < 0.001

  1. Statistical analysis was carried out with the Mann-Whitney test.
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Immunity & Ageing

ISSN: 1742-4933

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