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Table 2 Risk of any dementia and Alzheimer Disease by quartiles of plasma total homocysteine and serum folate

From: The Conselice Study of Brain Ageing

  Any Dementia AD
  HR [95% Confidence Interval] P value HR (95% Confidence Interval) P value
Quartiles of plasma total homocysteine, μmol/L     
< 10.1 1.00   1.00  
10.1 to 12.5 1.73 [0.87 – 3.46] 0.117 2.43 [0.96 – 6.13] 0.062
12.6 to 15.0 2.02 [0.96 – 4.23] 0.060 2.43 [0.96 – 6.13] 0.060
> 15.00 3.55 [1.72 – 7.29] 0.001 4.33 [1.73 – 10.8] 0.002
Quartiles of serum folate, nmol/L     
< 8.9 2.22 [1.21 – 4.05] 0.010 2.04 [1.02 – 4.09] 0.045
8.9 to 11.8 1.83 [1.00 – 3.34] 0.050 1.30 [0.62 – 2.72] 0.484
11.9 to 15.2 1.16 [0.60 – 2.24] 0.064 0.66 [0.29 – 1.54] 0.340
> 15.2 1.00   1.00  
  1. Data are for 816 subjects; the number of incident dementia cases was 112 for any dementia and 70 for Alzheimer’s Disease (AD).
  2. Hazard Ratios (HR) are adjusted for age, gender, education, APOE genotype, creatinine, serum levels of folate and vitamin B12, stroke, smoking status, diabetes, hypertension, cardiovascular disease, and body-mass-index.