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Figure 4 | Immunity & Ageing

Figure 4

From: Aging impacts isolated lymphoid follicle development and function

Figure 4

ILFs from aged mice express lower levels of chemokines and chemokine receptors demonstrated to play a role recruiting B-lymphocytes into ILFs. RNA was isolated from pooled ILFs from aged and young mice. The mRNA expression of CCL20, CXCL13, CCR6, and CXCR5 was evaluated using real time PCR (panel a), and the protein expression for intestinal CCL20 and CXCL13 was measured by ELISA (panel b). ILFs from aged mice showed decreased mRNA expression of chemokines CCL20 (~3 fold), CXCL13 (~4 fold) and their respective receptors CCR6 (~3.5 fold), CXCR5 (~6 fold) (panel a), and significantly decreased intestinal protein expression of CCL20 and CXCL13 (panel b). * = p < 0.05.

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