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Table 2 The effect of age and cytomegalovirus (CMV) serostatus on the various T lymphocytes for healthy donors

From: Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets

  young (20-40 yrs) elderly (> 60 yrs)
  CMV- (N = 15) CMV+ (N = 17)   CMV- (N = 21) CMV+ (N = 23)  
  mean ± SEM mean ± SEM P-value mean ± SEM mean ± SEM P-value
T lymphocytes 0.77 ± 0.07 1.39 ± 0.13 < 0.01 0.91 ± 0.1 1.03 ± 0.09 0.19
CD4+ T lymphocytes 0.49 ± 0.06 0.86 ± 0.09 < 0.01 0.63 ± 0.08 0.63 ± 0.06 0.74
Tnaive 0.17 ± 0.02 0.36 ± 0.05 0.01 0.25 ± 0.05 0.21 ± 0.03 0.61
Tcm 0.2 ± 0.03 0.26 ± 0.02 0.08 0.21 ± 0.02 0.23 ± 0.03 0.91
Tem 0.07 ± 0.01 0.15 ± 0.02 < 0.01 0.08 ± 0.01 0.11 ± 0.01 0.05
Tmem 0.27 ± 0.04 0.4 ± 0.04 0.02 0.29 ± 0.03 0.34 ± 0.04 0.38
*CD28null 0.11 ± 0.02 4.21 ± 0.98 < 0.01 0.34 ± 0.17 4.73 ± 1.36 < 0.01
*CD57+ 5.23 ± 0.71 18.11 ± 3.88 0.04 6.46 ± 0.69 13.18 ± 3.77 0.34
CD8+ T lymphocytes 0.23 ± 0.02 0.42 ± 0.04 < 0.01 0.22 ± 0.03 0.34 ± 0.03 < 0.01
Tnaive 0.15 ± 0.03 0.22 ± 0.04 0.28 0.06 ± 0.01 0.06 ± 0.01 0.54
Tcm 0.04 ± 0.01 0.04 ± 0.01 0.77 0.05 ± 0.01 0.08 ± 0.02 0.55
Tem 0.06 ± 0.01 0.09 ± 0.02 0.08 0.07 ± 0.01 0.11 ± 0.02 0.05
Temra 0.04 ± 0.01 0.09 ± 0.02 0.01 0.06 ± 0.02 0.11 ± 0.02 0.01
Tmem 0.14 ± 0.01 0.23 ± 0.03 0.01 0.18 ± 0.03 0.3 ± 0.03 < 0.01
*CD28null 31.89 ± 5.12 47.82 ± 4.13 0.04 27.78 ± 3.52 43.28 ± 4.47 0.02
*CD57+ 38.39 ± 8.67 49.63 ± 6.14 0.34 29.21 ± 2.79 49.65 ± 9.38 0.03
CD4/CD8 ratio 2.06 ± 0.35 2.13 ± 0.18 0.571 3.58 ± 0.38 2.05 ± 0.20 < 0.01
  1. absolute values are 106/mL, Tmem is sum of Tcm+Tem or sum of Tcm+Tem+Temra for CD4 and CD8 T lymphocytes, respectively
  2. * are percentages of CD4+ and CD8+ Tmem lymphocytes, respectively.
  3. P-values represent the comparison between CMV- and CMV+