| |
young (20-40 yrs)
|
elderly (> 60 yrs)
|
|---|
| |
CMV- (N = 15)
|
CMV+ (N = 17)
| |
CMV- (N = 21)
|
CMV+ (N = 23)
| |
|---|
| |
mean ± SEM
|
mean ± SEM
|
P-value
|
mean ± SEM
|
mean ± SEM
|
P-value
|
|---|
|
T lymphocytes
|
0.77 ± 0.07
|
1.39 ± 0.13
|
< 0.01
|
0.91 ± 0.1
|
1.03 ± 0.09
|
0.19
|
|
CD4+ T lymphocytes
|
0.49 ± 0.06
|
0.86 ± 0.09
|
< 0.01
|
0.63 ± 0.08
|
0.63 ± 0.06
|
0.74
|
|
Tnaive
|
0.17 ± 0.02
|
0.36 ± 0.05
|
0.01
|
0.25 ± 0.05
|
0.21 ± 0.03
|
0.61
|
|
Tcm
|
0.2 ± 0.03
|
0.26 ± 0.02
|
0.08
|
0.21 ± 0.02
|
0.23 ± 0.03
|
0.91
|
|
Tem
|
0.07 ± 0.01
|
0.15 ± 0.02
|
< 0.01
|
0.08 ± 0.01
|
0.11 ± 0.01
|
0.05
|
|
Tmem
|
0.27 ± 0.04
|
0.4 ± 0.04
|
0.02
|
0.29 ± 0.03
|
0.34 ± 0.04
|
0.38
|
|
*CD28null
|
0.11 ± 0.02
|
4.21 ± 0.98
|
< 0.01
|
0.34 ± 0.17
|
4.73 ± 1.36
|
< 0.01
|
|
*CD57+
|
5.23 ± 0.71
|
18.11 ± 3.88
|
0.04
|
6.46 ± 0.69
|
13.18 ± 3.77
|
0.34
|
|
CD8+ T lymphocytes
|
0.23 ± 0.02
|
0.42 ± 0.04
|
< 0.01
|
0.22 ± 0.03
|
0.34 ± 0.03
|
< 0.01
|
|
Tnaive
|
0.15 ± 0.03
|
0.22 ± 0.04
|
0.28
|
0.06 ± 0.01
|
0.06 ± 0.01
|
0.54
|
|
Tcm
|
0.04 ± 0.01
|
0.04 ± 0.01
|
0.77
|
0.05 ± 0.01
|
0.08 ± 0.02
|
0.55
|
|
Tem
|
0.06 ± 0.01
|
0.09 ± 0.02
|
0.08
|
0.07 ± 0.01
|
0.11 ± 0.02
|
0.05
|
|
Temra
|
0.04 ± 0.01
|
0.09 ± 0.02
|
0.01
|
0.06 ± 0.02
|
0.11 ± 0.02
|
0.01
|
|
Tmem
|
0.14 ± 0.01
|
0.23 ± 0.03
|
0.01
|
0.18 ± 0.03
|
0.3 ± 0.03
|
< 0.01
|
|
*CD28null
|
31.89 ± 5.12
|
47.82 ± 4.13
|
0.04
|
27.78 ± 3.52
|
43.28 ± 4.47
|
0.02
|
|
*CD57+
|
38.39 ± 8.67
|
49.63 ± 6.14
|
0.34
|
29.21 ± 2.79
|
49.65 ± 9.38
|
0.03
|
|
CD4/CD8 ratio
|
2.06 ± 0.35
|
2.13 ± 0.18
|
0.571
|
3.58 ± 0.38
|
2.05 ± 0.20
|
< 0.01
|
- absolute values are 106/mL, Tmem is sum of Tcm+Tem or sum of Tcm+Tem+Temra for CD4 and CD8 T lymphocytes, respectively
- * are percentages of CD4+ and CD8+ Tmem lymphocytes, respectively.
- P-values represent the comparison between CMV- and CMV+
