Immunity & Ageing

Table 2 The effect of age and cytomegalovirus (CMV) serostatus on the various T lymphocytes for healthy donors

From: Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets

	young (20-40 yrs)			elderly (> 60 yrs)
	CMV- (N = 15)	CMV+ (N = 17)		CMV- (N = 21)	CMV+ (N = 23)
	mean ± SEM	mean ± SEM	P-value	mean ± SEM	mean ± SEM	P-value
T lymphocytes	0.77 ± 0.07	1.39 ± 0.13	< 0.01	0.91 ± 0.1	1.03 ± 0.09	0.19
CD4⁺ T lymphocytes	0.49 ± 0.06	0.86 ± 0.09	< 0.01	0.63 ± 0.08	0.63 ± 0.06	0.74
Tnaive	0.17 ± 0.02	0.36 ± 0.05	0.01	0.25 ± 0.05	0.21 ± 0.03	0.61
Tcm	0.2 ± 0.03	0.26 ± 0.02	0.08	0.21 ± 0.02	0.23 ± 0.03	0.91
Tem	0.07 ± 0.01	0.15 ± 0.02	< 0.01	0.08 ± 0.01	0.11 ± 0.01	0.05
Tmem	0.27 ± 0.04	0.4 ± 0.04	0.02	0.29 ± 0.03	0.34 ± 0.04	0.38
*CD28null	0.11 ± 0.02	4.21 ± 0.98	< 0.01	0.34 ± 0.17	4.73 ± 1.36	< 0.01
*CD57⁺	5.23 ± 0.71	18.11 ± 3.88	0.04	6.46 ± 0.69	13.18 ± 3.77	0.34
CD8⁺ T lymphocytes	0.23 ± 0.02	0.42 ± 0.04	< 0.01	0.22 ± 0.03	0.34 ± 0.03	< 0.01
Tnaive	0.15 ± 0.03	0.22 ± 0.04	0.28	0.06 ± 0.01	0.06 ± 0.01	0.54
Tcm	0.04 ± 0.01	0.04 ± 0.01	0.77	0.05 ± 0.01	0.08 ± 0.02	0.55
Tem	0.06 ± 0.01	0.09 ± 0.02	0.08	0.07 ± 0.01	0.11 ± 0.02	0.05
Temra	0.04 ± 0.01	0.09 ± 0.02	0.01	0.06 ± 0.02	0.11 ± 0.02	0.01
Tmem	0.14 ± 0.01	0.23 ± 0.03	0.01	0.18 ± 0.03	0.3 ± 0.03	< 0.01
*CD28null	31.89 ± 5.12	47.82 ± 4.13	0.04	27.78 ± 3.52	43.28 ± 4.47	0.02
*CD57⁺	38.39 ± 8.67	49.63 ± 6.14	0.34	29.21 ± 2.79	49.65 ± 9.38	0.03
CD4/CD8 ratio	2.06 ± 0.35	2.13 ± 0.18	0.571	3.58 ± 0.38	2.05 ± 0.20	< 0.01

absolute values are 10⁶/mL, Tmem is sum of Tcm+Tem or sum of Tcm+Tem+Temra for CD4 and CD8 T lymphocytes, respectively
* are percentages of CD4+ and CD8+ Tmem lymphocytes, respectively.
P-values represent the comparison between CMV- and CMV+

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