Immunity & Ageing

Table 3 The effect of age and cytomegalovirus (CMV) serostatus on the various T lymphocytes for ESRD patients

From: Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets

	young (20-40 yrs)			elderly (> 60 yrs)
	CMV- (N = 27)	CMV+ (N = 23)		CMV- (N = 15)	CMV+ (N = 25)
	mean ± SEM	mean ± SEM	P-value	mean ± SEM	mean ± SEM	P-value
T lymphocytes	0.72 ± 0.08	0.86 ± 0.1	0.47	0.48 ± 0.04	0.6 ± 0.04	0.09
CD4⁺ T lymphocytes	0.46 ± 0.05	0.46 ± 0.06	0.90	0.35 ± 0.03	0.36 ± 0.03	0.87
Tnaive	0.2 ± 0.03	0.17 ± 0.04	0.73	0.13 ± 0.02	0.08 ± 0.01	0.03
Tcm	0.15 ± 0.02	0.14 ± 0.02	0.61	0.13 ± 0.02	0.13 ± 0.02	0.85
Tem	0.07 ± 0.01	0.09 ± 0.02	0.52	0.06 ± 0.01	0.09 ± 0.01	0.01
Tmem	0.21 ± 0.02	0.23 ± 0.03	0.93	0.18 ± 0.03	0.22 ± 0.02	0.28
*CD28null	0.05 ± 0.01	4.05 ± 0.83	< 0.01	0.82 ± 0.69	11.91 ± 2.79	< 0.01
*CD57⁺	9.93 ± 1.24	34.02 ± 7.09	< 0.01	7.61 ± 1.77	35.71 ± 7.15	< 0.01
CD8⁺ T lymphocytes	0.23 ± 0.03	0.34 ± 0.04	0.02	0.17 ± 0.02	0.22 ± 0.03	< 0.01
Tnaive	0.13 ± 0.02	0.11 ± 0.01	0.64	0.03 ± 0.01	0.03 ± 0.01	0.51
Tcm	0.04 ± 0.01	0.03 ± 0.01	0.59	0.04 ± 0.01	0.03 ± 0.01	0.64
Tem	0.07 ± 0.02	0.07 ± 0.02	0.73	0.06 ± 0.01	0.06 ± 0.01	0.76
Temra	0.02 ± 0.01	0.12 ± 0.02	< 0.01	0.02 ± 0.01	0.11 ± 0.02	< 0.01
Tmem	0.13 ± 0.03	0.22 ± 0.04	0.03	0.12 ± 0.02	0.19 ± 0.03	0.02
*CD28null	26.73 ± 2.82	50.95 ± 5.55	< 0.01	24.92 ± 3.51	50.45 ± 4.44	< 0.01
*CD57⁺	26.71 ± 5.11	68.12 ± 6.7	< 0.01	34.09 ± 4.83	55.22 ± 7.26	0.06
CD4/CD8 ratio	2.32 ± 0.27	1.62 ± 0.18	< 0.01	4.37 ± 0.90	2.0 ± 0.20	< 0.01

absolute values are 10⁶/mL, Tmem is sum of Tcm+Tem or sum of Tcm+Tem+Temra for CD4 and CD8 T lymphocytes, respectively
* are percentages of CD4+ and CD8+ Tmem lymphocytes, respectively.
P-values represent the comparison between CMV- and CMV+

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