| |
young (20-40 yrs)
|
elderly (> 60 yrs)
|
|---|
| |
CMV- (N = 27)
|
CMV+ (N = 23)
| |
CMV- (N = 15)
|
CMV+ (N = 25)
| |
|---|
| |
mean ± SEM
|
mean ± SEM
|
P-value
|
mean ± SEM
|
mean ± SEM
|
P-value
|
|---|
|
T lymphocytes
|
0.72 ± 0.08
|
0.86 ± 0.1
|
0.47
|
0.48 ± 0.04
|
0.6 ± 0.04
|
0.09
|
|
CD4+ T lymphocytes
|
0.46 ± 0.05
|
0.46 ± 0.06
|
0.90
|
0.35 ± 0.03
|
0.36 ± 0.03
|
0.87
|
|
Tnaive
|
0.2 ± 0.03
|
0.17 ± 0.04
|
0.73
|
0.13 ± 0.02
|
0.08 ± 0.01
|
0.03
|
|
Tcm
|
0.15 ± 0.02
|
0.14 ± 0.02
|
0.61
|
0.13 ± 0.02
|
0.13 ± 0.02
|
0.85
|
|
Tem
|
0.07 ± 0.01
|
0.09 ± 0.02
|
0.52
|
0.06 ± 0.01
|
0.09 ± 0.01
|
0.01
|
|
Tmem
|
0.21 ± 0.02
|
0.23 ± 0.03
|
0.93
|
0.18 ± 0.03
|
0.22 ± 0.02
|
0.28
|
|
*CD28null
|
0.05 ± 0.01
|
4.05 ± 0.83
|
< 0.01
|
0.82 ± 0.69
|
11.91 ± 2.79
|
< 0.01
|
|
*CD57+
|
9.93 ± 1.24
|
34.02 ± 7.09
|
< 0.01
|
7.61 ± 1.77
|
35.71 ± 7.15
|
< 0.01
|
|
CD8+ T lymphocytes
|
0.23 ± 0.03
|
0.34 ± 0.04
|
0.02
|
0.17 ± 0.02
|
0.22 ± 0.03
|
< 0.01
|
|
Tnaive
|
0.13 ± 0.02
|
0.11 ± 0.01
|
0.64
|
0.03 ± 0.01
|
0.03 ± 0.01
|
0.51
|
|
Tcm
|
0.04 ± 0.01
|
0.03 ± 0.01
|
0.59
|
0.04 ± 0.01
|
0.03 ± 0.01
|
0.64
|
|
Tem
|
0.07 ± 0.02
|
0.07 ± 0.02
|
0.73
|
0.06 ± 0.01
|
0.06 ± 0.01
|
0.76
|
|
Temra
|
0.02 ± 0.01
|
0.12 ± 0.02
|
< 0.01
|
0.02 ± 0.01
|
0.11 ± 0.02
|
< 0.01
|
|
Tmem
|
0.13 ± 0.03
|
0.22 ± 0.04
|
0.03
|
0.12 ± 0.02
|
0.19 ± 0.03
|
0.02
|
|
*CD28null
|
26.73 ± 2.82
|
50.95 ± 5.55
|
< 0.01
|
24.92 ± 3.51
|
50.45 ± 4.44
|
< 0.01
|
|
*CD57+
|
26.71 ± 5.11
|
68.12 ± 6.7
|
< 0.01
|
34.09 ± 4.83
|
55.22 ± 7.26
|
0.06
|
|
CD4/CD8 ratio
|
2.32 ± 0.27
|
1.62 ± 0.18
|
< 0.01
|
4.37 ± 0.90
|
2.0 ± 0.20
|
< 0.01
|
- absolute values are 106/mL, Tmem is sum of Tcm+Tem or sum of Tcm+Tem+Temra for CD4 and CD8 T lymphocytes, respectively
- * are percentages of CD4+ and CD8+ Tmem lymphocytes, respectively.
- P-values represent the comparison between CMV- and CMV+
