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Table 3 The effect of age and cytomegalovirus (CMV) serostatus on the various T lymphocytes for ESRD patients

From: Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets

  young (20-40 yrs) elderly (> 60 yrs)
  CMV- (N = 27) CMV+ (N = 23)   CMV- (N = 15) CMV+ (N = 25)  
  mean ± SEM mean ± SEM P-value mean ± SEM mean ± SEM P-value
T lymphocytes 0.72 ± 0.08 0.86 ± 0.1 0.47 0.48 ± 0.04 0.6 ± 0.04 0.09
CD4+ T lymphocytes 0.46 ± 0.05 0.46 ± 0.06 0.90 0.35 ± 0.03 0.36 ± 0.03 0.87
Tnaive 0.2 ± 0.03 0.17 ± 0.04 0.73 0.13 ± 0.02 0.08 ± 0.01 0.03
Tcm 0.15 ± 0.02 0.14 ± 0.02 0.61 0.13 ± 0.02 0.13 ± 0.02 0.85
Tem 0.07 ± 0.01 0.09 ± 0.02 0.52 0.06 ± 0.01 0.09 ± 0.01 0.01
Tmem 0.21 ± 0.02 0.23 ± 0.03 0.93 0.18 ± 0.03 0.22 ± 0.02 0.28
*CD28null 0.05 ± 0.01 4.05 ± 0.83 < 0.01 0.82 ± 0.69 11.91 ± 2.79 < 0.01
*CD57+ 9.93 ± 1.24 34.02 ± 7.09 < 0.01 7.61 ± 1.77 35.71 ± 7.15 < 0.01
CD8+ T lymphocytes 0.23 ± 0.03 0.34 ± 0.04 0.02 0.17 ± 0.02 0.22 ± 0.03 < 0.01
Tnaive 0.13 ± 0.02 0.11 ± 0.01 0.64 0.03 ± 0.01 0.03 ± 0.01 0.51
Tcm 0.04 ± 0.01 0.03 ± 0.01 0.59 0.04 ± 0.01 0.03 ± 0.01 0.64
Tem 0.07 ± 0.02 0.07 ± 0.02 0.73 0.06 ± 0.01 0.06 ± 0.01 0.76
Temra 0.02 ± 0.01 0.12 ± 0.02 < 0.01 0.02 ± 0.01 0.11 ± 0.02 < 0.01
Tmem 0.13 ± 0.03 0.22 ± 0.04 0.03 0.12 ± 0.02 0.19 ± 0.03 0.02
*CD28null 26.73 ± 2.82 50.95 ± 5.55 < 0.01 24.92 ± 3.51 50.45 ± 4.44 < 0.01
*CD57+ 26.71 ± 5.11 68.12 ± 6.7 < 0.01 34.09 ± 4.83 55.22 ± 7.26 0.06
CD4/CD8 ratio 2.32 ± 0.27 1.62 ± 0.18 < 0.01 4.37 ± 0.90 2.0 ± 0.20 < 0.01
  1. absolute values are 106/mL, Tmem is sum of Tcm+Tem or sum of Tcm+Tem+Temra for CD4 and CD8 T lymphocytes, respectively
  2. * are percentages of CD4+ and CD8+ Tmem lymphocytes, respectively.
  3. P-values represent the comparison between CMV- and CMV+