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Table 1 Differently expressed genes in early versus replicative senescent and CMV-infected versus untreated human lung fibroblasts

From: The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence

  Gene symbol Gene name Fold regulation in
replicative senescent fibroblasts (mean ± S.E.M.)
Maximally observed fold regulation (mean ± S.E.M.) following CMV-infection
Apoptosis CASP1 Caspase 1 - 2.4 ± 1.3
  CASP4 Caspase 4 - 2.3 ± 1.3
  TGFB1 Transforming growth factor, beta 1 - 2.1 ± 0.9
  TNFRSF1A Tumor necrosis factor receptor superfamily, member 1A - 2.4 ± 1.6
Complement activation C5 Complement component 5 - 2.3 ± 1.5
  C8A Complement component 8, alpha polypeptide 6.8 ± 0.8 -
  CD55 CD55 molecule, accelerating factor for complement - 4.3 ± 0.9
Cytokines, chemokines and their receptors CCL2 Chemokine (C-C motif) ligand 2 - 2.8 ± 1.8
  CXCR4 Chemokine receptor 4 - 57.8 ± 1.5
  IFNA1 Interferon, alpha 1 3.7 ± 0.3 -
  IFNGR1 Interferon gamma receptor 1 2.0 ± 0.4 3.2 ± 1.6
  IFNGR2 Interferon gamma receptor 2 - 2.2 ± 1.6
  IL1A Interleukin 1, alpha 6.4 ± 0.2 6.4 ± 1.6
  IL1B Interleukin 1, beta 4.1 ± 0.1 8.9 ± 1.7
  IL1F5 Interleukin 1 family, member 5 3.2 ± 1.2 -
  IL1F7 Interleukin 1 family, member 7 8.9 ± 0.8 -
  IL6 Interleukin 6 (interferon, beta 2) 10.2 ± 0.04 8.1 ± 1.5
  TNF Tumor necrosis factor 3.2 ± 0.4 -
Detection of pathogens TLR2 Toll-like receptor 2 - 6.1 ± 5.4
  TLR3 Toll-like receptor 3 - 5.9 ± 3.9
  TLR4 Toll-like receptor 4 3.8 ± 0.9 5.4 ± 4.7
  TLR6 Toll-like receptor 6 3.0 ± 0.2 -
  TOLLIP Toll interacting protein - 2.5 ± 1.3
Defense response CAMP Cathelicidin antimicrobial peptide 8.3 ± 0.6 -
  FN1 Fibronectin 1 2.5 ± 0.2 -
IL1receptor pathway IL1R1 Interleukin 1 receptor, type I - 2.9 ± 1.2
  IL1RL2 Interleukin 1 receptor-like 2 - 5.3 ± 2.5
  IL1RAP Interleukin 1 receptor accessory protein - 2.4 ± 1.8
  IKBKB Inhibitor of kappa light polypeptide gene enhancer 2.8 ± 0.2 -
  MAPK8 Mitogen activated protein kinase 8 - 2.5 ± 1.5
  MAPK14 Mitogen activated protein kinase 14 - 2.5 ± 1.3
Inflammatory response ADORA2A Adenosine A2a receptor 12.2 ± 3.0 4.2 ± 4.2
  CCR3 Chemokine (C-C motif) receptor 3 12.3 ± 0.8 -
  CD14 CD14 molecule 29.1 ± 1.0 -
  CYBB Cytochrome b-245, beta polypeptide 8.5 ± 0.5 -
  IRAK1 Interleukin-1 receptor-associated kinase 1 - 3.2 ± 1.7
  IRAK2 Interleukin-1 receptor-associated kinase 2 2.4 ± 0.04 2.7 ± 1.5
  NOS2A Nitric oxide synthase 2A (inducible) 4.7 ± 0.9 -
  PTAFR Platelet-activating factor receptor 4.5 ± 1.4 -
Innate immune response DMBT1 Deleted in malignant brain tumors 1 8.9 ± 1.4 -
  PGLYRP1 Peptidoglycan recognition protein 1 10.7 ± 1.8 -
  PGLYRP3 Peptidoglycan recognition protein 3 12.0 ± 1.1 -
  SFTPD Surfactant, pulmonary-associated protein D 10.0 ± 1.1 -
NFkB pathway CHUK Conserved helix-loop-helix ubiquitous kinase - 2.1 ± 1.3
  MyD88 Myeloid differentiation primary response gene - 3.9 ± 1.8
  NFKB2 Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (p49/p100) - 3.2 ± 1.6
  NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha - 2.0 ± 0.9
  TRAF6 TNF receptor-associated factor 6 - 2.3 ± 1.5
Other group COLEC12 Collectin subfamily member 12 2.2 ± 0.2 -
  HMOX1 Heme oxygenase 1 - 2.0 ± 1.0
  IRF1 Interferon regulatory factor 1 - 3.4 ± 1.8
  LY96 Lymphocyte antigen 96 - 2.6 ± 1.7
  NLRC4 NLR family, CARD domain containing 4 2.3 ± 0.2 2.7 ± 1.6
  TREM1 Triggering receptor expressed on myeloid cells 1 4.1 ± 1.1 10.0 ± 2.8
  1. The fold regulation data represent the mean ± S.E.M. of three independent experiments calculated for each examined group and time point.