Table 1 Differently expressed genes in early versus replicative senescent and CMV-infected versus untreated human lung fibroblasts

Apoptosis

CASP1

Caspase 1

-

2.4 ± 1.3

CASP4

Caspase 4

-

2.3 ± 1.3

TGFB1

Transforming growth factor, beta 1

-

2.1 ± 0.9

TNFRSF1A

Tumor necrosis factor receptor superfamily, member 1A

-

2.4 ± 1.6

Complement activation

C5

Complement component 5

-

2.3 ± 1.5

C8A

Complement component 8, alpha polypeptide

6.8 ± 0.8

-

CD55

CD55 molecule, accelerating factor for complement

-

4.3 ± 0.9

Cytokines, chemokines and their receptors

CCL2

Chemokine (C-C motif) ligand 2

-

2.8 ± 1.8

CXCR4

Chemokine receptor 4

-

57.8 ± 1.5

IFNA1

Interferon, alpha 1

3.7 ± 0.3

-

IFNGR1

Interferon gamma receptor 1

2.0 ± 0.4

3.2 ± 1.6

IFNGR2

Interferon gamma receptor 2

-

2.2 ± 1.6

IL1A

Interleukin 1, alpha

6.4 ± 0.2

6.4 ± 1.6

IL1B

Interleukin 1, beta

4.1 ± 0.1

8.9 ± 1.7

IL1F5

Interleukin 1 family, member 5

3.2 ± 1.2

-

IL1F7

Interleukin 1 family, member 7

8.9 ± 0.8

-

IL6

Interleukin 6 (interferon, beta 2)

10.2 ± 0.04

8.1 ± 1.5

TNF

Tumor necrosis factor

3.2 ± 0.4

-

Detection of pathogens

TLR2

Toll-like receptor 2

-

6.1 ± 5.4

TLR3

Toll-like receptor 3

-

5.9 ± 3.9

TLR4

Toll-like receptor 4

3.8 ± 0.9

5.4 ± 4.7

TLR6

Toll-like receptor 6

3.0 ± 0.2

-

TOLLIP

Toll interacting protein

-

2.5 ± 1.3

Defense response

CAMP

Cathelicidin antimicrobial peptide

8.3 ± 0.6

-

FN1

Fibronectin 1

2.5 ± 0.2

-

IL1receptor pathway

IL1R1

Interleukin 1 receptor, type I

-

2.9 ± 1.2

IL1RL2

Interleukin 1 receptor-like 2

-

5.3 ± 2.5

IL1RAP

Interleukin 1 receptor accessory protein

-

2.4 ± 1.8

IKBKB

Inhibitor of kappa light polypeptide gene enhancer

2.8 ± 0.2

-

MAPK8

Mitogen activated protein kinase 8

-

2.5 ± 1.5

MAPK14

Mitogen activated protein kinase 14

-

2.5 ± 1.3

Inflammatory response

ADORA2A

Adenosine A2a receptor

12.2 ± 3.0

4.2 ± 4.2

CCR3

Chemokine (C-C motif) receptor 3

12.3 ± 0.8

-

CD14

CD14 molecule

29.1 ± 1.0

-

CYBB

Cytochrome b-245, beta polypeptide

8.5 ± 0.5

-

IRAK1

Interleukin-1 receptor-associated kinase 1

-

3.2 ± 1.7

IRAK2

Interleukin-1 receptor-associated kinase 2

2.4 ± 0.04

2.7 ± 1.5

NOS2A

Nitric oxide synthase 2A (inducible)

4.7 ± 0.9

-

PTAFR

Platelet-activating factor receptor

4.5 ± 1.4

-

Innate immune response

DMBT1

Deleted in malignant brain tumors 1

8.9 ± 1.4

-

PGLYRP1

Peptidoglycan recognition protein 1

10.7 ± 1.8

-

PGLYRP3

Peptidoglycan recognition protein 3

12.0 ± 1.1

-

SFTPD

Surfactant, pulmonary-associated protein D

10.0 ± 1.1

-

NFkB pathway

CHUK

Conserved helix-loop-helix ubiquitous kinase

-

2.1 ± 1.3

MyD88

Myeloid differentiation primary response gene

-

3.9 ± 1.8

NFKB2

Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (p49/p100)

-

3.2 ± 1.6

NFKBIA

Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

-

2.0 ± 0.9

TRAF6

TNF receptor-associated factor 6

-

2.3 ± 1.5

Other group

COLEC12

Collectin subfamily member 12

2.2 ± 0.2

-

HMOX1

Heme oxygenase 1

-

2.0 ± 1.0

IRF1

Interferon regulatory factor 1

-

3.4 ± 1.8

LY96

Lymphocyte antigen 96

-

2.6 ± 1.7

NLRC4

NLR family, CARD domain containing 4

2.3 ± 0.2

2.7 ± 1.6

TREM1

Triggering receptor expressed on myeloid cells 1

4.1 ± 1.1

10.0 ± 2.8