Skip to main content
Figure 5 | Immunity & Ageing

Figure 5

From: Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells

Figure 5

Schematic representation of putative lymphocyte migration pathway through Zizimin2. A) In BMDC, constitutively expressed FcγRIII or TLR4 is activated by each ligand, resulting in the activation of Zizimin2 with the conversion from its unstable to stable form. Then the Zizimin2 interacts with plasma membrane through its own PH domain and activates Cdc42, followed by activation of the downstream effectors, consequently induces filopodial formation for migration to sites the pathogens infected. Significantly, aging induces down-regulation of Zizimin2 expression, resulting in reduction of filopodial formation. B) In B cells, for TLR4 signaling is cardinally active as in BMDC might be caused, except eventually lamellipodial formation. It might be capable for FcγRIIB to transduce a inhibitory function against Zizimin2 while the signal from TLR4 comes out.

Back to article page