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Figure 1 | Immunity & Ageing

Figure 1

From: Alzheimer disease and platelets: how’s that relevant

Figure 1

Principal platelet membrane receptors and signal transduction pathways. Different receptors are stimulated by various agonists, almost converging in increasing intracellular Ca2+ concentration. Platelet activation induces an inside out signaling pathway that active αIIbβ3 integrin. The subsequently link of αIIbβ3 with fibrinogen lead to an outside in signaling pathway that promotes irreversible aggregation. Abbreviations: TXA2, tromboxane A2; THR, thrombin; PAR1, protease-activated receptor-1; VWF, Von Willebrand Factor; RGD, arginine, glycine, aspartic acid; GPIb-IX-V, glycoprotein Ib-IX-V; FcγRIIA, cristallizable fragment γ receptorIIA; αIIbβ3, αIIbβ3 integrin; cAMP, cyclic adenosin monophosphate; P2Y12, P2Y12 receptor; P2Y1, P2Y1 receptor; ADP, adenosin diphosphate; 5HT, 5-hydroxytryptamine; APP, amyloid precursor protein; GPVI, glicoprotein VI; α2β1, α2β1 integrin; Syk, Syk tyrosin kinase; PLCγ2, phospholipase γ2; DAG, diacilglicerol; PKC, protein kinase C; IP3, inositol 3-phosphate, Ca2+, calcium, PLA2, phspholipase A2; AA, arachidonic acid; COX, ciclooxigenase; PLCβ, Phospholipaseβ.

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