Homeostatic role of IFNy pathway and IFNy-dependence of IL2 pathway in heathy men. In the APC analysis, in heathy men (Figure 2) IFNγ level decreases with aging, however the IL2 level seems to be a better candidate than IFNγ. The authors use their mathematical modeling to verify the IFNγ role as a gender-specific pathway, by excluding from the model IL2 and IFNy alternately. The graphs obtained from this analysis, clearly define the homeostatic role of IFNy and IFNy-dependence of IL2. Indeed, excluding IL2 reports from the network of cytokines are not affected, however the exclusion of IFNy completely reshapes these relationships.