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Figure 6 | Immunity & Ageing

Figure 6

From: The discovery of how gender influences age immunological mechanisms in health and disease, and the identification of ageing gender-specific biomarkers, could lead to specifically tailored treatment and ultimately improve therapeutic success rates

Figure 6

The normal level of "dual gender specific cytokines" in all “dual gender biomarkers”, is an index for an healthy state because it is an indicator of the ability to maintain physiological homeostasis. Level variation of "dual gender specific cytokines" (for example IFNγ-IL10, IL6-IL4 and IFNγ-IL4 in men) in a direction that agrees with the positive or negative sign of their healthy relationship (in this case positive), it is an index for a transient inflammation, because it is still an indicator of immune system homeostasis. Level variation of "dual gender specific cytokines" in a direction that does not agree (in this case negative) with the positive or negative sign of their healthy relationship, it is index for a chronic inflammation, because it is an indicator of loss of homeostatic ability.

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