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Table 1 Gender-dependent immune pathways or molecules that causes different disease susceptibility in men and women

From: The discovery of how gender influences age immunological mechanisms in health and disease, and the identification of ageing gender-specific biomarkers, could lead to specifically tailored treatment and ultimately improve therapeutic success rates

Gender dependent immune pathways or molecules Disease susceptibility References
Caspase-12 long variant infectious diseases Yeretssian G, Proc Natl Acad Sci, 2009, 106:9016
Glucocorticoid receptor pathways infectious diseases Wynne O, Stress, 2011, 14:247
Sulfur-dependent detoxification pathways autism Al-Yafee YA, BMC Neurol, 2011, 11:139
MyD88-dependent pathway type 1 diabetes Sheng H J, Immunol, 2011, 187:1591
STAT5-dependent pathway human growth disorders Davey HW, Am J Hum Genet, 1999, 65:959
Toll-like receptor 4 chronic pain Sorge RE, J Neurosci, 2011, 31:15450
B7-H1-dependent pathway melanoma Lin PY, J Immunol, 2010, 185:2747
PARP-1-dependent pathway lupus nephritis Caricchio R, NIH RePORTER, 2012, 08 01
HLA-DRB1*0401 and HLA-DQ8 arthritis Behrens M, J Autoimmun, 2011, 37:95
Rac1, NOX, ROS kaposi's sarcoma Goldschmidt CPJ, NIH RePORTER, 2010, 05 01
CTLA4 hepatitis C Schott E, J Hepatol. 2007, 46:372
Toll-like receptor 7 chronic HCV-infection Schott E, J Hepatol, 2007, 47:203
Aim2 and p202 proteins systemic lupus erythematosus Panchanathan R, Mol Immunol, 2011, 49:273
Retinoid x receptor alpha hepatocellular carcinogenesis Guo M, BMC Genomics, 2008, 9:403
MAPK signaling systemic lupus erythematosus Xie H, Arthritis Rheum; 2011, 63:2425