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Table 5 Pairwise Pearson correlation between circulating cytokine and chemokine levels in rhesus macaques a

From: Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta)

  IFN-γ IL-1β IL-6 IL-12/ 23 (p40) IL-15 TNF-α MCP-1 MIP-1α IL-1ra IL-4 MIP-1β IL-17 MIF Eotaxin IL-8 I-TAC MDC MIG RANTES
IFN-γ                    
IL-1β 0.406                   
IL-6 0.725 0.425                  
IL-12/23(p40) 0.408 0.763 0.341                 
IL-15 0.476 0.853 0.434 0.768                
TNF-α 0.668 0.470 0.438 0.534 0.527               
MCP-1 0.276 0.637 0.332 0.466 0.561 0.286              
MIP-1α 0.689 0.788 0.664 0.712 0.779 0.582 0.507             
IL-1ra 0.377 0.855 0.376 0.893 0.843 0.509 0.597 0.772            
IL-4 0.320 0.932 0.395 0.814 0.828 0.441 0.626 0.771 0.927           
MIP-1β 0.723 0.449 0.565 0.374 0.445 0.184 0.262 0.690 0.355 0.351          
IL-17 0.075 0.174 −0.003 0.575 0.317 0.155 0.132 0.306 0.475 0.226 0.166         
MIF −0.086 0.263 −0.221 0.008 0.054 0.096 −0.063 −0.013 0.177 0.456 −0.092 0.015        
Eotaxin 0.344 0.933 0.113 −0.271 0.298 0.239 0.672 0.366 −0.170 −0.202 0.278 −0.155 0.163       
IL-8 −0.112 −0.355 −0.094 −0.285 −0.317 −0.085 −0.029 −0.331 −0.308 −0.329 −0.303 −0.115 0.513 −0.125      
I-TAC 0.443 0.222 0.425 −0.143 0.518 0.070 0.397 0.473 0.241 −0.233 0.356 0.148 0.094 0.393 −0.070     
MDC −0.102 −0.160 −0.245 −0.034 −0.108 −0.125 −0.171 −0.171 0.086 0.142 −0.071 −0.126 −0.029 −0.211 0.024 −0.137    
MIG 0.039 0.191 −0.128 0.349 0.097 0.376 0.079 −0.006 −0.259 −0.376 0.023 0.138 −0.186 0.187 −0.263 0.121 0.023   
RANTES −0.065 −0.162 −0.237 0.730 0.148 0.415 −0.085 0.137 0.547 0.271 0.004 0.613 0.225 −0.210 0.041 −0.181 −0.009 −0.020  
  1. a Pairwise Pearson correlation coefficients (r values) were measured among cytokines and chemokines using GraphPad Prism software. Statistically significant (P < 0.05) correlation coefficients are designated in bold text. The inner box designates concordant correlation coefficients that were significant for each pair of inflammatory cytokines and chemokines tested within the group and the outer box also includes the two anti-inflammatory cytokines with significant correlation coefficients between each pairwise evaluation.