Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta)

Didier, Elizabeth S; Sugimoto, Chie; Bowers, Lisa C; Khan, Imtiaz A; Kuroda, Marcelo J

doi:10.1186/1742-4933-9-25

Immunity & Ageing

Table 5 Pairwise Pearson correlation between circulating cytokine and chemokine levels in rhesus macaques ^a

From: Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta)

	IFN-γ	IL-1β	IL-6	IL-12/ 23 (p40)	IL-15	TNF-α	MCP-1	MIP-1α	IL-1ra	IL-4	MIP-1β	IL-17	MIF	Eotaxin	IL-8	I-TAC	MDC	MIG
IFN-γ
IL-1β	0.406
IL-6	0.725	0.425
IL-12/23(p40)	0.408	0.763	0.341
IL-15	0.476	0.853	0.434	0.768
TNF-α	0.668	0.470	0.438	0.534	0.527
MCP-1	0.276	0.637	0.332	0.466	0.561	0.286
MIP-1α	0.689	0.788	0.664	0.712	0.779	0.582	0.507
IL-1ra	0.377	0.855	0.376	0.893	0.843	0.509	0.597	0.772
IL-4	0.320	0.932	0.395	0.814	0.828	0.441	0.626	0.771	0.927
MIP-1β	0.723	0.449	0.565	0.374	0.445	0.184	0.262	0.690	0.355	0.351
IL-17	0.075	0.174	−0.003	0.575	0.317	0.155	0.132	0.306	0.475	0.226	0.166
MIF	−0.086	0.263	−0.221	0.008	0.054	0.096	−0.063	−0.013	0.177	0.456	−0.092	0.015
Eotaxin	0.344	0.933	0.113	−0.271	0.298	0.239	0.672	0.366	−0.170	−0.202	0.278	−0.155	0.163
IL-8	−0.112	−0.355	−0.094	−0.285	−0.317	−0.085	−0.029	−0.331	−0.308	−0.329	−0.303	−0.115	0.513	−0.125
I-TAC	0.443	0.222	0.425	−0.143	0.518	0.070	0.397	0.473	0.241	−0.233	0.356	0.148	0.094	0.393	−0.070
MDC	−0.102	−0.160	−0.245	−0.034	−0.108	−0.125	−0.171	−0.171	0.086	0.142	−0.071	−0.126	−0.029	−0.211	0.024	−0.137
MIG	0.039	0.191	−0.128	0.349	0.097	0.376	0.079	−0.006	−0.259	−0.376	0.023	0.138	−0.186	0.187	−0.263	0.121	0.023
RANTES	−0.065	−0.162	−0.237	0.730	0.148	0.415	−0.085	0.137	0.547	0.271	0.004	0.613	0.225	−0.210	0.041	−0.181	−0.009	−0.020

^a Pairwise Pearson correlation coefficients (r values) were measured among cytokines and chemokines using GraphPad Prism software. Statistically significant (P < 0.05) correlation coefficients are designated in bold text. The inner box designates concordant correlation coefficients that were significant for each pair of inflammatory cytokines and chemokines tested within the group and the outer box also includes the two anti-inflammatory cytokines with significant correlation coefficients between each pairwise evaluation.

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ISSN: 1742-4933

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