Figure 1

Progressive dysregulation of the virus-specific CD8⁺T cell repertoire over time. Cohorts of 200 and 100 B6 mice were infected with Sendai virus and bled at 1 (100 mouse cohort), 8, 12, 15 and 19 (200 mouse cohort) months post infection. A, The frequency of NP_324-332K^b+ cells among total CD8⁺ T cells and B, frequency of Vβ8⁺ cells among NP_324-332K^b+ cells for each individual mouse is graphed over time. C, The percentage of 5HNP_324-332K^b+ cells relative to NP_324-332K^b+ cells is shown, filled red circles indicate mice with frequencies greater than 3SDs from the normal frequency observed at 1 month (horizontal line). D, The frequency of NP_324-332K^b+ cells among total CD8⁺ T cells is shown for mice with increased 5H and are indicated by red filled circles. In all panels, horizontal line indicates frequency greater than 3SDs from the normal frequency observed at 1 month. In panels C and D, blue squares and triangles represent mouse 139 and 28 respectively.