Table 1 Genes and variants found correlated with longevity in humans
Gene | Variant | Occurrence in centenarians | Previous disease correlations | Potential role in longevity | Ref. |
|---|---|---|---|---|---|
APOE | ε4* | reduced | Alzheimer’s and cardiovascular diseases | Maintenance of vascular integrity | [7] |
FOXO3A | rs2802292* | more present | none | Control of cell homeostasis | [20] |
CAMK4 | rs10491334†| more present | hypertension | Modulation of CREB, SIRT and FOXO3A | [21] |
ATXN1 | rs697739 | more present | amyotrophic lateral sclerosis (age of onset) | Modulation of CREB | [21] |
DCAMKL1 | rs9315385 | more present | heart rate variability | Modulation of CREB | [21] |