Table 3 Data from our investigations in Sicilian population

N = 35 females

N = 106 females

HFE

C282

47 (84%)

132 (0%)

8.3 × 10^-5 [33]

282Y

9 (16%)

0 (0%)

Genes

Alleles of SNPs or genetic variants

Centenarians

Young controls (< 55 years)

MI patients (< 55 years)

P

N = 55 males

N = 127 males

N = 105 males

TLR4

+896A

94 (85.4%)

239 (94.1%)

205 (97.6%)

< 0.001 [49]

+896 G

16 (14.6%)

15 (5.9%)

5 (2.4%)

N = 123 males

N = 136 males

N = 133 males

CCR5

WT

221(89.8%)

252 (92.6%)

263 (98.8%)

0.00006 [48]

Δ32

25 (10.2%)

20 (7.4%)

3 (1.2%)

N = 96 males

N = 170 males

N = 140 males

Cox-2

-765 G

122 (63.5%)

240 (70.6%)

232(82.8%)

0.000007 [47]

-765 C

70(36.5%)

100(29.4%)

48(17.2%)

5-Lo

-1708 G

180 (93.7%)

302(88.8%)

224(80%)

0.00003 [47]

-1708A

12(6.3%)

38(11.2%)

56(20%)

0.001

21 C

176(91.7%)

299(88%)

225(80.4%)

21 T

16(8.3%)

41(12%)

55(19.6%)

Genes

Alleles of SNPs or genetic variants

Centenarians

Young controls (< 55 years)

PC patients (< 55 years)

P

N = 55 males

N = 125 males

N = 50 males

TLR4

+896A

94 (85%)

235 (94%)

99 (99%)

0.001 [54]

+896 G

16 (15%)

15 (6%)

1 (1%)

Cox-2

-765 G

67 (61%)

176 (70%)

77 (77%)

0.05

5-Lo

-765 C

43 (39%)

74 (30%)

23(23%)

0.0007

-1708 G

104 (95%)

223 (89%)

77 (77%)

-1708A

6 (5%)

27 (11%)

23 (23%)

N = 53 males

N = 50 males

CCR5

WT

95 (89.6%)

97 (97%)

0.03 [53]

Δ32

11(10.4%)

3(3%)

Gene

Alleles of SNPs or genetic variants

Centenarians

Young controls (< 55 years)

BF patients (30-60 years)

P

N = 42 females

N = 42 females

N = 42 females

TLR4

+896A

81 (96.4%)

78 (92.9%)

76 (90.4%)

0.003 [55]

+ 896 G

3 (3.6%)

6 (7.1%)

8 (9.6%)