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Table 3 Data from our investigations in Sicilian population

From: Genetics of longevity. Data from the studies on Sicilian centenarians

Gene Alleles of genetic variants Centenarians Young controls (< 55 years)   P
   N = 35 females N = 106 females   
HFE C282 47 (84%) 132 (0%)   8.3 × 10-5 [33]
  282Y 9 (16%) 0 (0%)   
Genes Alleles of SNPs or genetic variants Centenarians Young controls (< 55 years) MI patients (< 55 years) P
   N = 55 males N = 127 males N = 105 males  
TLR4 +896A 94 (85.4%) 239 (94.1%) 205 (97.6%) < 0.001 [49]
  +896 G 16 (14.6%) 15 (5.9%) 5 (2.4%)  
   N = 123 males N = 136 males N = 133 males  
CCR5 WT 221(89.8%) 252 (92.6%) 263 (98.8%) 0.00006 [48]
  Δ32 25 (10.2%) 20 (7.4%) 3 (1.2%)  
   N = 96 males N = 170 males N = 140 males  
Cox-2 -765 G 122 (63.5%) 240 (70.6%) 232(82.8%) 0.000007 [47]
  -765 C 70(36.5%) 100(29.4%) 48(17.2%)  
5-Lo -1708 G 180 (93.7%) 302(88.8%) 224(80%) 0.00003 [47]
  -1708A 12(6.3%) 38(11.2%) 56(20%) 0.001
  21 C 176(91.7%) 299(88%) 225(80.4%)  
  21 T 16(8.3%) 41(12%) 55(19.6%)  
Genes Alleles of SNPs or genetic variants Centenarians Young controls (< 55 years) PC patients (< 55 years) P
   N = 55 males N = 125 males N = 50 males  
TLR4 +896A 94 (85%) 235 (94%) 99 (99%) 0.001 [54]
  +896 G 16 (15%) 15 (6%) 1 (1%)  
Cox-2 -765 G 67 (61%) 176 (70%) 77 (77%) 0.05
5-Lo -765 C 43 (39%) 74 (30%) 23(23%) 0.0007
  -1708 G 104 (95%) 223 (89%) 77 (77%)  
  -1708A 6 (5%) 27 (11%) 23 (23%)  
   N = 53 males   N = 50 males  
CCR5 WT 95 (89.6%)   97 (97%) 0.03 [53]
  Δ32 11(10.4%)   3(3%)  
Gene Alleles of SNPs or genetic variants Centenarians Young controls (< 55 years) BF patients (30-60 years) P
   N = 42 females N = 42 females N = 42 females  
TLR4 +896A 81 (96.4%) 78 (92.9%) 76 (90.4%) 0.003 [55]
  + 896 G 3 (3.6%) 6 (7.1%) 8 (9.6%)