Table 4 Cytokine data from our studies in Sicilian population
From: Genetics of longevity. Data from the studies on Sicilian centenarians
Gene | Genotypes | Centenarians | Young controls (< 55 years) | Â | P |
|---|---|---|---|---|---|
| Â | Â | N = 31 males | N = 161 males | Â | Â |
IL-10 | -1082GG | 18 (58%) | 55 (34%) | Â | < 0.025 [61] |
| Â | -1083GA | 9 (29%) | 88 (55%) | Â | Â |
| Â | -1082AA | 4 (13%) | 18 (11%) | Â | Â |
| Â | Â | N = 72 males | N = 115 males | Â | Â |
IL-10 | -1082GG | 33 (46%) | 32(28%) | Â | 0.019 [62] |
| Â | -1083GA | 34(47%) | 64(56%) | Â | Â |
| Â | -1082AA | 5(7%) | 19(16%) | Â | Â |
| Â | Â | Centenarians | Young controls (< 55 years) | MI patients (< 55 years) | P |
| Â | Â | N = 52 males | N = 110 males | N = 90 males | Â |
IL-10 | -1082GG | 25 (48.1%) | 26(23.6%) | 17 (18.9%) | 0.003 [63] |
| Â | -1083GA | 23 (44.2%) | 56 (50.9%) | 29 (32.2%) | Â |
| Â | -1082AA | 6(11.5%) | 28 (25.5%) | 44 (48.9%) | Â |
Genes | Alleles of SNP | Centenarians | Young controls (< 55 years) | Â | P |
| Â | Â | N = 142 females | N = 90 females | Â | Â |
IFN-γ | +874 T | 102 (35.9%) | 85 (47.2%) |  | 0.02 [60] |
| Â | + 874A | 182 (64.1%) | 95 (52.8%) | Â | Â |