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Table 1 GSH:GSSG ratio of TCCs + / - Ebselen

From: SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence’ effects of ebselen and N-acetyl cysteine in human T cell clone cultures

Times in culture (Weeks) 30μM ebselen 400-23 (26 yr ol) 385-7 (45 yr old) 399-37 (80 yr old)
2 - 42.3 ± 1.7 44.3 ± 2.4 37.7 ± 0.4*
2 + 44.0 ± 1.7 41.9 ± 1.2 36.7 ± 0.9*
5 - 44.2 ± 2.8 42.0 ± 1.8 30.8 ± 2.0*
5 + 47.3 ± 2.4 46.8 ± 5.1 31.3 ± 1.5*
9/10 - 36.1 ± 1.6 33.4 ± 4.1 25.5 ± 0.7*
9/10 + 37.2 ± 1.4 36.3 ± 2.9 26.6 ± 0.8*
  1. GSH:GSSG ratios in three pooled CD4+ TCCs (+ / - 30 μM Ebselen) derived from a healthy 80 year old donor are significantly lower than in either of the three pooled TCCs, each derived from a healthy 26 or a 45 year old donor (published data from [10]).
  2. *Significantly lower GSH:GSSG ratio in 399-37 clones (80 year old) compared to either 400-23 (26 year old) or 385-7 (45 year old) clones.