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Table 2 GSH:GSSG ratio of TCCs + / - NAC

From: SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence’ effects of ebselen and N-acetyl cysteine in human T cell clone cultures

Time in culture (Weeks) 7.5 mM NAC 400-23 (26 yr old) 385-7 (45 yr old) 399-37 (80 yr old)
2 - 46.3 ± 2.5 44.2 ± 0.8 36.7 ± 1.0*
2 + 51.2 ± 4.5 46.7 ± 3.3 35.7 ± 0.9*
5 - 37.9 ± 0.8 41.0 ± 0.5 29.4 ± 1.2*
5 + 42.5 ± 2.5 46.1 ± 0.3 30.7 ± 1.8*
9/10 - 35.5 ± 4.0 33.2 ± 3.1 24.2 ± 0.2*
9/10 + 35.8 ± 2.3 36.6 ± 2.6 24.1 ± 0.2*
  1. GSH:GSSG ratios in three pooled CD4+ TCCs (+ / - 7.5 mM NAC) derived from a healthy 80 year old donor are significantly lower than the levels in either of the three pooled TCCs, each derived from a healthy 26 or a 45 year old donor (published data from [10]).
  2. *Significantly lower GSH:GSSG ratio in 399-37 clones (80 year old) compared to either 400-23 (26 year old) or 385-7 (45 year old) clones.