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Table 3 Hearing impairment risk of inflammatory mediators related SNPs analyzed using logistic regression with generalized estimating equations

From: The association between hearing impairment and polymorphisms of genes encoding inflammatory mediators in Japanese aged population

Gene

rs No

Crude: model 1

Adjusted: model 2

Adjusted: model 3

  

Odds ration

95% CI

p value

Odds ration

95% CI

p value

Odds ration

95% CI

p value

TNF- α

rs1800630

         
 

Hearing impairment criteria

         
 

PTABE 1)>25 dB

1.120

0.979-1.281

0.100

1.192

1.020-1.392

0.027

1.172

1.005-1.367

0.044

 

PTABE 40 dB

1.090

0.885-1.344

0.417

1.109

0.884-1.390

0.372

1.106

0.884-1.384

0.380

TNFRSF1B

rs1061624

         
 

PTABE >25 dB

1.151

1.021-1.297

0.022

1.210

1.052-1.393

0.008

1.211

1.053-1.392

0.007

 

PTABE >40 dB

1.272

1.052-1.538

0.013

1.293

1.045-1.599

0.018

1.275

1.026-1.584

0.028

IL1A

rs1800587

         
 

PTABE >25 dB

1.093

0.894-1.335

0.386

1.061

0.845-1.331

0.611

1.070

0.855-1.339

0.557

 

PTABE >40 dB

0.975

0.692-1.373

0.885

0.946

0.660-1.354

0.760

0.956

0.667-1.371

0.807

IL1B

rs16944

         
 

PTABE >25 dB

0.941

0.834-1.060

0.316

0.915

0.796-1.052

0.212

0.920

0.801-1.057

0.238

 

PTABE >40 dB

0.924

0.762-1.121

0.422

0.960

0.774-1.190

0.706

0.945

0.760-1.174

0.608

IL-4

Rrs1801275

         
 

PTABE >25 dB

0.986

0.829-172

0.872

1.038

0.851-1.265

0.715

1.031

0.847-1.255

0.761

 

PTABE >40 dB

0.968

0.729-1.85

0.822

1.010

0.746-1.367

0.949

1.050

0.774-1.424

0.756

IL-6

rs1800796

         
 

PTABE >25 dB

1.011

0.881-1.161

0.872

1.083

0.924-1.269

0.327

1.079

0.922-1.262

0.343

 

PTABE >40 dB

1.034

0.829-1.289

0.770

1.042

0.822-1.320

0.734

1.056

0.833-1.339

0.651

IL-10

rs1800872

         
 

PTABE >25 dB

0.981

0.864-1.114

0.764

0.983

0.844-1.145

0.826

0.973

0.838-1.131

0.725

 

PTABE >40 dB

0.887

0.714-1.102

0.280

0.860

0.572-1.101

0.231

0.834

0.651-1.070

0.153

IRAK-1

rs1059702

         
 

PTABE >25 dB

1.026

0.912-1.55

0.666

1.012

0.889-1.151

0.862

1.010

0.888-1.148

0.885

 

PTABE >40 dB

0.887

0.718-1.097

0.268

0.8161

0.707-1.051

0.141

0.869

0.713-1.058

0.162

CRP2

rs1130864

         
 

PTABE >25 dB

0.976

0.758-1.257

0.81

1.099

0.816-1.479

0.535

1.092

0.817-1.461

0.552

 

PTABE >40 dB

0.924

0.624-1.363

0.692

1.081

0.711-1.643

0.715

1.113

0.726-1.705

0.623

  1. 1)PTABE : pure-tone average threshold at 0.5, 1, 2 and 4 kHz for the better ear.
  2. Moderating variables.
  3. model 1 : No variables.
  4. model 2 : Age and sex.
  5. model 3 : Any history of noise exposure, ear disease, hypertension, diabetes, dyslipidemia, stroke and cardiac disease, and lifetime smoking habit in addition to those of model 2.