Table 5 Genotype distribution of participants at first-wave examinations of NILS-LSA before application of exclusion criteria, and comparison with those of HapMap-JPT or another public database
Gene | rs No | Allele1) | Genotype N= 2149, Number (%) | p-value | ||
|---|---|---|---|---|---|---|
TNF-α | rs1800630 | A (C) | CC | CA | AA | |
Our baseline subjects | 1551 (72.2) | 431 (20.0) | 167 (7.8) | NS | ||
HapMap-JPT | (71.1) | (20.0) | (8.9) | |||
TNFRSF1B | rs1061624 | A (G) | GG | GA | AA | |
Our baseline subjects | 519 (24.1) | 1070 (49.8) | 560 (26.1) | NS | ||
HapMap-JPT | (29.4) | (48.2) | (22.4) | |||
IL1A | rs1800587 | T (C) | CC | CT | TT | |
Our baseline subjects | 1745 (81.2) | 385 (17.9) | 19 (0.9) | NS | ||
HapMap-JPT | (76.7) | (20.9) | (2.3) | |||
IL1B | rs16944 | T (C) | CC | CT | TT | |
Our baseline subjects | 600 (27.9) | 1096 (51.0) | 453 (21.1) | NS | ||
PGA-UW-FHCRC: JPT_GENO_PANEL2) | (26.3) | (50.0) | (23.7) | |||
IL-4R | rs1801275 | G (A) | AA | AG | GG | |
Our baseline subjects | 1585 (73.8) | 522 (24.3) | 42 (1.9) | 0.034 | ||
HapMap-JPT | (81.4) | (18.6) | (0) | |||
IL-6 | rs1800796 | G (C) | CC | CG | GG | |
Our baseline subjects | 1257 (58.5) | 762 (35.5) | 130 (6.0) | 0.007 | ||
HapMap-JPT | (75.0) | (22.7) | (2.3) | |||
IL-10 | rs1800872 | C (A) | AA | AC | CC | |
Our baseline subjects | 985 (45.8) | 938 (43.7) | 226 (10.5) | NS | ||
HapMap-JPT | (44.4) | (51.1) | (4.4) | |||
IRAK-1 | rs1059702 | C (T) | TT | TC | CC | |
Our baseline subjects | 1444 (67.2) | 406 (18.9) | 299 (13.9) | NS | ||
HapMap-JPT | (66.3) | (19.8) | (14.0) | |||
CRP2 | rs1130864 | T (C) | CC | CT | TT | |
Our baseline subjects | 1889 (87.9) | 251 (11.7) | 9 (0.4) | NS | ||
HapMap-JPT | (87.2) | (11.6) | (1.2) | |||