Table 1 Effects of persistent virus infections upon the different T cell populations in the peripheral blood of young and old subjects [modified from Fülöp et al[41]
CMV | HBV | EBV | VZV | HSV-1 | HHV-6 | |
|---|---|---|---|---|---|---|
Expansion | +++ | + | + | - | - | ? |
Viral load | +/− | +/− | +/− | +/− | +/− | +/− |
Reactivation | ? | ? | ? | +/− | +/− | - |
Immune phenotype | TEMRA | EM | EM | CM/EM | EM | TREG |
Immunological aging | ++++ | + | ++ | - | - | - |
Clinical impact in young | Moderate | Mild | Moderate | Mild | Mild | Moderate/Severe |
Clinical impact in elderly | Moderate | Mild | Moderate | Severe | Mild | ? |