Skip to main content

Table 1 Effects of persistent virus infections upon the different T cell populations in the peripheral blood of young and old subjects [modified from Fülöp et al[41]

From: The 21st century epidemic: infections as inductors of neuro-degeneration associated with Alzheimer’s Disease

  CMV HBV EBV VZV HSV-1 HHV-6
Expansion +++ + + - - ?
Viral load +/− +/− +/− +/− +/− +/−
Reactivation ? ? ? +/− +/− -
Immune phenotype TEMRA EM EM CM/EM EM TREG
Immunological aging ++++ + ++ - - -
Clinical impact in young Moderate Mild Moderate Mild Mild Moderate/Severe
Clinical impact in elderly Moderate Mild Moderate Severe Mild ?
  1. CM = central memory cells; EM = effector memory cells; TEMRA = terminally differentiated memory cells re-expressing CD45RA.
  2. ? = data not available.