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Figure 5 | Immunity & Ageing

Figure 5

From: The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation

Figure 5

Reduction in marginal zone B cell percentage in B cell-specific Ziz2 KO mice. (A) Splenocytes were analyzed by flow cytometry for T1 (Transition 1) and MZ B cells in CD23− cells. T1: IgM+ CD21−. MZ: IgM+ CD21+. (B) The percentage of MZ B cells was lower in CD19Cre/+; Ziz2flox (Conditional KO) mice than in CD19Cre/+ (Control) mice. (C) Splenocytes were analyzed by flow cytometry for T2 and mature (M) B cells in CD23+ cells. T2: IgMhigh CD21+. M: IgMlow/middle CD21+. (D) The percentage of “M” was not altered in KO mice. **: P < 0.01 Between seven and ten mice (9–11 weeks old, male or female) per group from five independent experiments (from one to three mice per group per experiment) were used.

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