Figure 8

Marginal zone B cell regions were narrowed in Ziz2 KO mice. (A-B) Splenic sections were stained with anti-CD1d (Magenta), anti-CD169 (Green) (B), and anti-SIGN-R1(Blue) antibodies (A) Three mice per group were used. Between one and eight follicles per mouse (per section) were captured. All mice were 10 weeks old. Scale bars: 100 μm. (C) The CD1d-positive region outside CD169-positive cells was significantly narrower in Ziz2 KO mice than in the other groups. 2KO: Ziz2 KO. 3KO: Ziz3 KO. **: P < 0.01 ***: P < 0.0001 N = 7–15.