Figure 6
From: The interplay between immune maturation, age, chronic viral infection and environment
Cytokine responses of adolescent SPF-2 and non-SPF macaques to ConA stimulation. Panel (A). The individual graphs show the production of specific cytokines in PBMC of SPF-2 (open triangles; n = 20) or non-SPF adolescent macaques (filled triangles; n = 10) after in vitro stimulation with Con A. Cytokines were measured in culture supernatants at 48 hours. Capped lines with p values indicate statistically significant differences between the two groups determined by Mann–Whitney test. Each symbol represents an individual animal; horizontal lines indicate the median of the age group. Panel (B) shows how the cytokine ratios of IL-12:IL-10 and IFN-γ:IL-4 differ between adolescent SPF-2 and non-SPF macaques.