The interplay between immune maturation, age, chronic viral infection and environment

Immunity & Ageing

Table 1 Peripheral blood mononuclear cell populations in SPF-2 rhesus macaques

Cell population	Median cell numbers/ μl blood (Minimum-Maximum)
	Infants ^a	Adolescents	Infants vs. Adolescents ^b	Young Adults	Adolescents vs. Young Adults ^b
	(n = 22)	(n = 30)	Infants vs. Adolescents ^b	(n = 8)	Adolescents vs. Young Adults ^b
Neutrophils	1952	10502	p < 0.0001	11274	NS^c
Neutrophils	(990–4900)	(6667–18502)	p < 0.0001	(10032–19694)	NS^c
Monocytes	182	328	p = 0.0354	938	p < 0.0001
Monocytes	(45–637)	(202–855)	p = 0.0354	(476–2030)	p < 0.0001
Lymphocytes	4547	1949	p < 0.0001	710	p = 0.0014
Lymphocytes	(2277–7314)	(1107–3088)	p < 0.0001	(342–2388)	p = 0.0014
B Cells^d	1464	474	p < 0.0001	224	p = 0.0252
B Cells^d	(649–2716)	(136–808)	p < 0.0001	(97–736)	p = 0.0252
T Cells^e	2759	1257	p < 0.0001	486	p = 0.0031
T Cells^e	(1373–4811)	(336–1899)	p < 0.0001	(194–1760)	p = 0.0031
CD4⁺ T	1863	828	p < 0.0001	124	p < 0.0001
CD4⁺ T	(850–3598)	(459–1319)	p < 0.0001	(15–734)	p < 0.0001
CD8⁺ T	820	397	p < 0.0001	363	NS
CD8⁺ T	(357–1843)	(209–1109)	p < 0.0001	(179–1026)	NS
CD4:CD8 Ratio	2.3	2.0	NS	0.4	p < 0.0001
CD4:CD8 Ratio	(1.2-3.6)	(0.7-3.8)	NS	(0.1-0.8)	p < 0.0001

^aage: 40 weeks; ^bGroup comparison was performed by Mann–Whitney test; ^cNS = not significant; ^dB cells are defined as CD20⁺ lymphocytes; ^eT cells are defined as CD3⁺ lymphocytes.

ISSN: 1742-4933