Table 5 Cytokine responses to in vitro ConA stimulation
From: The interplay between immune maturation, age, chronic viral infection and environment
Cytokine | Median cytokine levels in pg/ ml (Minimum-Maximum) | ||||
|---|---|---|---|---|---|
SPF-2 Adolescents | Non-SPF Adolescents | SPF-2 vs. Non-SPF Adolescents a | Non-SPF Adults | Non-SPF Adolescents vs. Adults a | |
Inflammatory | |||||
IL-6 | 58.0 | 647.7 | p < 0.0500 | 1267.0 | NSb |
(8.6-1451) | (207.6-1778) | (268.2-2253) | |||
TNF- | 1198.0 | 3436.0 | p < 0.0010 | 6181.0 | p < 0.0500 |
(48.2-4103) | (1260.0-6368.0) | (2246–9517) | |||
IL-1β | 23.4 | 113.7 | p < 0.0010 | 226.3 | NS |
(0.3-71.4) | (25.5-259.0) | (80.9-795.9) | |||
TNF-β | 334.7 | 1185.0 | p < 0.0010 | 753.2 | NS |
(31.5-1089.0) | (104.6-2307.0) | (232.3-1465.0) | |||
IL-12p40 | 1174.0 | 167.3 | p < 0.0001 | 215.8 | NS |
(592.9-2068.0) | (15.1-260.8) | (96.2-606.6) | |||
IL-15 | 4.0 | 11.3 | p < 0.001 | 11.1 | NS |
(1.9-8.9) | (0–16.2) | (7.6-15.6) | |||
CXCL-10 | 33.0 | 13.1 | p < 0.0001 | 10.6 | NS |
(16.2-45.0) | (3.0-23.4) | (0.1-22.0) | |||
Anti-Inflammatory | |||||
IL-10 | 53.5 | 171.2 | p = 0.0251 | 489.7 | p = 0.0115 |
(3.5-974.9) | (20.0-453.0) | (72.3-978.1) | |||
IL-1Rα | 6073.0 | 529.7 | p < 0.0001 | 937.8 | p = 0.0279 |
(1775–15352) | (48.2-887.4) | (266.6-3574.0) | |||
Th differentiation | |||||
IL-2 | 2451.0 | 4892.0 | NS | 3511.0 | NS |
(19.4-21229.0) | (40.6-7656.0) | (814.1-23975) | |||
IFN-γ | 681.0 | 16058.0 | p < 0.0010 | 19656 | NS |
(5.2-5832.0) | (2704–20164) | (14315–20941) | |||
IL-4 | 1.3 | 3.9 | p < 0.0500 | 9.3 | p = 0.0015 |
(0.3-7.3) | (1.1-8.6) | (4.2-21.7) | |||
IL-9 | 259.2 | 20.5 | p < 0.0001 | 38.2 | p = 0.0089 |
(126.2-512.0) | (9.8-47.9) | (24.2-103.3) | |||
Chemokines | |||||
RANTES | 11017.0 | 970.5 | p < 0.0001 | 1818.0 | p = 0.0089 |
(800.3-37070) | (151.8-2041.0) | (930.2-3434.0) | |||
Eotaxin | 13.3 | 21.3 | p = 0.0301 | 21.7 | NS |
(4.1-24.1) | (8.0-31.2) | (1.5-25.5) | |||
Cytokine Ratios | |||||
IL-12:IL-10 | 24.1 | 0.7 | p < 0.0010 | 0.3 | NS |
(0.8-326) | (0.2-1.1) | (0.2-0.8) | |||
IFN-γ:IL-4 | 508.2 | 4329.0 | p < 0.0010 | 2032.0 | p = 0.0350 |
(17.8-8997.0) | (484.6-12917) | (886.0-4871.0) | |||
IL-1β:IL-1Rα | 0.004 | 0.36 | p < 0.0001 | 0.27 | NS |
(0.0-0.0096) | (0.04-3.69) | (0.06-0.88) | |||
RANTES:Eotaxin | 611.3 | 41.0 | p < 0.0001 | 79.8 | p = 0.0435 |
(64.1-8074.0) | (16.7-158.1) | (52.9-1353.0) | |||