Table 2 Genotype distribution in the German and Lithuanian cohort
From: Less functional variants of TLR-1/-6/-10 genes are associated with age
German cohort | Young subjects (Age < 50, n = 866) | Old subjects (Age ≥ 50, n = 523) | P-value | ||||
Wt (%) | Het (%) | Hom (%) | Wt (%) | Het (%) | Hom (%) | ||
TLR-6 (P249S)a | 336 (38.8) | 399 (46.1) | 130 (24.9) | 158 (30.2) | 256 (48.9) | 109 (20.8) | 0.001 |
TLR-1 | 70 | 300 | 495 | 15 | 184 | 324 | <0.001 |
prom. | (8.1) | (34.6) | (57.2) | (2.9) | (35.2) | (62.0) | |
TLR-1 | 68 | 303 | 494 | 15 | 173 | 335 | <0.001 |
(N248S) | (7.9) | (35.0) | (57.0) | (2.9) | (33.1) | (64.1) | |
TLR-1 | 91 | 329 | 445 | 21 | 186 | 316 | <0.001 |
(I602S) | (10.5) | (38.0) | (52.4) | (4.0) | (35.6) | (60.4) | |
TLR-10 | 603 | 231 | 31 | 371 | 142 | 10 | 0.205 |
(V775L) | (69.6) | (26.7) | (3.6) | (70.9) | (27.2) | (1.9) | |
Lithuanian cohort | Young subjects (Age < 50) | Old subjects (Age ≥ 50) | P-value | ||||
Wt (%) | Het (%) | Hom (%) | Wt (%) | Het (%) | Hom (%) | ||
TLR-6 (P249S) | 319 | 336 | 106 | 97 | 114 | 38 | 0.689 |
(n = 761, n = 250) | (41.9) | (44.2) | (13.9) | (38.8) | (45.6) | (15.2) | |
TLR-1 prom. | 25 | 222 | 515 | 4 | 52 | 194 | 0.009 |
(n = 762, n = 250) | (3.3) | (29.1) | (67.6) | (1.6) | (20.8) | (77.6) | |
TLR-1 (N248S) | 24 | 220 | 525 | 3 | 52 | 198 | 0.008 |
(n = 769, n = 251) | (3.1) | (28.6) | (68.3) | (1.2) | (20.7) | (78.9) | |
TLR-1 (I602S) | 29 | 242 | 498 | 7 | 58 | 189 | 0.018 |
(n = 762, n = 250 | (3.8) | (31.8) | (65.4) | (2.8) | (23.2) | (75.6) | |
TLR-10 (V775L) | 575 | 166 | 7 | 209 | 38 | 1 | 0.044 |
(n = 748, n = 248) | (76.9) | (22.2) | (0.9) | (84.3) | (15.3) | (0.4) | |