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Table 2 Genotype distribution in the German and Lithuanian cohort

From: Less functional variants of TLR-1/-6/-10 genes are associated with age

German cohort Young subjects (Age < 50, n = 866) Old subjects (Age ≥ 50, n = 523) P-value
  Wt (%) Het (%) Hom (%) Wt (%) Het (%) Hom (%)  
TLR-6 (P249S)a 336 (38.8) 399 (46.1) 130 (24.9) 158 (30.2) 256 (48.9) 109 (20.8) 0.001
TLR-1 70 300 495 15 184 324 <0.001
prom. (8.1) (34.6) (57.2) (2.9) (35.2) (62.0)  
TLR-1 68 303 494 15 173 335 <0.001
(N248S) (7.9) (35.0) (57.0) (2.9) (33.1) (64.1)  
TLR-1 91 329 445 21 186 316 <0.001
(I602S) (10.5) (38.0) (52.4) (4.0) (35.6) (60.4)  
TLR-10 603 231 31 371 142 10 0.205
(V775L) (69.6) (26.7) (3.6) (70.9) (27.2) (1.9)  
Lithuanian cohort Young subjects (Age < 50) Old subjects (Age ≥ 50) P-value
  Wt (%) Het (%) Hom (%) Wt (%) Het (%) Hom (%)  
TLR-6 (P249S) 319 336 106 97 114 38 0.689
(n = 761, n = 250) (41.9) (44.2) (13.9) (38.8) (45.6) (15.2)  
TLR-1 prom. 25 222 515 4 52 194 0.009
(n = 762, n = 250) (3.3) (29.1) (67.6) (1.6) (20.8) (77.6)  
TLR-1 (N248S) 24 220 525 3 52 198 0.008
(n = 769, n = 251) (3.1) (28.6) (68.3) (1.2) (20.7) (78.9)  
TLR-1 (I602S) 29 242 498 7 58 189 0.018
(n = 762, n = 250 (3.8) (31.8) (65.4) (2.8) (23.2) (75.6)  
TLR-10 (V775L) 575 166 7 209 38 1 0.044
(n = 748, n = 248) (76.9) (22.2) (0.9) (84.3) (15.3) (0.4)  
  1. P-values were determined by 3×2 Chi2 comparing young and old subjects. Significant P-values below 0.05 were printed in bold. Different sample numbers in the Lithuanian cohort are due to the fact that some samples failed to be genotyped for all SNPs.aTLR-6 genotypes for this cohort have mostly been published previously [17]