Table 4 Homozygous less functional genotypes are increased in older subjects
From: Less functional variants of TLR-1/-6/-10 genes are associated with age
Male | Female | |||
|---|---|---|---|---|
German | Odds ratio (95 % CI) | P-value | Odds ratio (95 % CI) | P-value |
TLR-6 (249S/S) | 1.41 (0.98–2.04) | 0.067 | 1.56 (0.97–2.50) | 0.066 |
TLR-1 prom. | 1.31 (0.98–1.76) | 0.065 | 1.02 (0.70–1.48) | 0.93 |
TLR-1 (248S/S) | 1.36 (1.02–1.81) | 0.038 | 1.31 (0.90-1.92) | 0.17 |
TLR-1 (602S/S) | 1.41 (1.06–1.87) | 0.02 | 1.53 (1.05–2.23) | 0.027 |
TLR-10 (775 V/V) | 1.05 (0.77–1.44) | 0.741 | 1.01 (0.69–1.54) | 0.89 |
Lithuanian | ||||
TLR-6 (249S/S) | 1.53 (0.89–2.62) | 0.123 | 0.88 (0.65–1.89) | 0.394 |
TLR-1 prom. | 1.46 (0.91–2.36) | 0.117 | 1.44 (1.13–1.83) | 0.003 |
TLR-1 (248S/S) | 1.42 (0.88–2.83) | 0.152 | 2.12 (1.30–3.43) | 0.002 |
TLR-1 (602S/S) | 1.77 (1.09–2.86) | 0.02 | 1.62 (1.04–2.53) | 0.033 |
TLR-10 (775 V/V) | 0.13 (0.36–1.14) | 0.132 | 0.52 (0.31–0.89) | 0.016 |
Combined | ||||
TLR-6 (249S/S) | 1.54 (1.15–2.05) | 0.003 | 1.16 (0.79–1.68) | 0.44 |
TLR-1 prom. | 1.12 (0.89–1.41) | 0.34 | 1.41 (1.06–1.89) | 0.018 |
TLR-1 (248S/S) | 1.13 (0.89–1.42) | 0.32 | 1.66 (1.24–2.23) | 0.001 |
TLR-1 (602S/S) | 1.18 (0.94–1.48) | 0.15 | 1.64 (1.28–2.19) | 0.001 |
TLR-10 (775 V/V) | 0.97 (0.75–1.25) | 0.79 | 0.73 (0.54–1.01) | 0.05 |