Skip to main content

Advertisement

Table 4 Homozygous less functional genotypes are increased in older subjects

From: Less functional variants of TLR-1/-6/-10 genes are associated with age

  Male Female
German Odds ratio (95 % CI) P-value Odds ratio (95 % CI) P-value
TLR-6 (249S/S) 1.41 (0.98–2.04) 0.067 1.56 (0.97–2.50) 0.066
TLR-1 prom. 1.31 (0.98–1.76) 0.065 1.02 (0.70–1.48) 0.93
TLR-1 (248S/S) 1.36 (1.02–1.81) 0.038 1.31 (0.90-1.92) 0.17
TLR-1 (602S/S) 1.41 (1.06–1.87) 0.02 1.53 (1.05–2.23) 0.027
TLR-10 (775 V/V) 1.05 (0.77–1.44) 0.741 1.01 (0.69–1.54) 0.89
Lithuanian     
TLR-6 (249S/S) 1.53 (0.89–2.62) 0.123 0.88 (0.65–1.89) 0.394
TLR-1 prom. 1.46 (0.91–2.36) 0.117 1.44 (1.13–1.83) 0.003
TLR-1 (248S/S) 1.42 (0.88–2.83) 0.152 2.12 (1.30–3.43) 0.002
TLR-1 (602S/S) 1.77 (1.09–2.86) 0.02 1.62 (1.04–2.53) 0.033
TLR-10 (775 V/V) 0.13 (0.36–1.14) 0.132 0.52 (0.31–0.89) 0.016
Combined     
TLR-6 (249S/S) 1.54 (1.15–2.05) 0.003 1.16 (0.79–1.68) 0.44
TLR-1 prom. 1.12 (0.89–1.41) 0.34 1.41 (1.06–1.89) 0.018
TLR-1 (248S/S) 1.13 (0.89–1.42) 0.32 1.66 (1.24–2.23) 0.001
TLR-1 (602S/S) 1.18 (0.94–1.48) 0.15 1.64 (1.28–2.19) 0.001
TLR-10 (775 V/V) 0.97 (0.75–1.25) 0.79 0.73 (0.54–1.01) 0.05
  1. Analysis was carried out by univariate logistic regression comparing the less functional homozygote genotype with the others in young versus old subjects. The reference were young subjects and the wild type + heterozygous genotype. Significant P-values below 0.05 were printed in bold