Table 5 Homozygous less functional genotypes are especially increased in 50–64 years old subjects
From: Less functional variants of TLR-1/-6/-10 genes are associated with age
Combined cohort | Male | Female | ||
|---|---|---|---|---|
TLR-6 (249 S/S) | Odds ratio (95 % CI) | P-value | Odds ratio (95 % CI) | P-value |
50–64 years | 1.52 (1.07–2.15) | 0.019 | 1.51 (0.99–2.30) | 0.056 |
65–74 years | 1.47 (0.94–2.29) | 0.093 | 0.55 (0.23–1.29) | 0.170 |
75–85 years | 1.83 (0.98–3.43) | 0.059 | 0.91 (0.37–2.20) | 0.827 |
TLR-1 prom. | ||||
50–64 years | 1.17 (0.88–1.56) | 0.271 | 1.79 (1.24–2.57) | 0.002 |
65–74 years | 1.03 (0.71–1.48) | 0.889 | 1.11 (0.66–1.85) | 0.697 |
75–85 years | 1.11 (0.64–1.93) | 0.707 | 0.90 (0.49–1.67) | 0.742 |
TLR-1 (248S/S) | ||||
50–64 years | 1.22 (0.91–1.62) | 0.180 | 1.85 (1.28–2.66) | 0.001 |
65–74 years | 1.01 (0.70–1.46) | 0.946 | 1.49 (0.87–2.54) | 0.149 |
75–85 years | 1.02 (0.59–1.76) | 0.947 | 1.31 (0.69–2.49) | 0.407 |
TLR-1 (602S/S) | ||||
50–64 years | 1.33 (1.00–1.76) | 0.047 | 1.76 (1.25–2.50) | 0.001 |
65–74 years | 1.09 (0.76–1.56) | 0.647 | 1.50 (0.90–2.49) | 0.122 |
75–85 years | 0.87 (0.51–1.47) | 0.591 | 1.45 (0.77–2.73) | 0.245 |
TLR-10 (775 V/V) | ||||
50–64 years | 0.99 (0.73–1.36) | 0.971 | 0.69 (0.46–1.01) | 0.057 |
65–74 years | 1.12 (0.76–1.669 | 0.569 | 0.65 (0.36–1.17) | 0.149 |
75–85 years | 1.01 (0.55–1.85) | 0.98 | 1.11 (0.58–2.13) | 0.763 |