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Table 5 Homozygous less functional genotypes are especially increased in 50–64 years old subjects

From: Less functional variants of TLR-1/-6/-10 genes are associated with age

Combined cohort Male Female
TLR-6 (249 S/S) Odds ratio (95 % CI) P-value Odds ratio (95 % CI) P-value
50–64 years 1.52 (1.07–2.15) 0.019 1.51 (0.99–2.30) 0.056
65–74 years 1.47 (0.94–2.29) 0.093 0.55 (0.23–1.29) 0.170
75–85 years 1.83 (0.98–3.43) 0.059 0.91 (0.37–2.20) 0.827
TLR-1 prom.     
50–64 years 1.17 (0.88–1.56) 0.271 1.79 (1.24–2.57) 0.002
65–74 years 1.03 (0.71–1.48) 0.889 1.11 (0.66–1.85) 0.697
75–85 years 1.11 (0.64–1.93) 0.707 0.90 (0.49–1.67) 0.742
TLR-1 (248S/S)     
50–64 years 1.22 (0.91–1.62) 0.180 1.85 (1.28–2.66) 0.001
65–74 years 1.01 (0.70–1.46) 0.946 1.49 (0.87–2.54) 0.149
75–85 years 1.02 (0.59–1.76) 0.947 1.31 (0.69–2.49) 0.407
TLR-1 (602S/S)     
50–64 years 1.33 (1.00–1.76) 0.047 1.76 (1.25–2.50) 0.001
65–74 years 1.09 (0.76–1.56) 0.647 1.50 (0.90–2.49) 0.122
75–85 years 0.87 (0.51–1.47) 0.591 1.45 (0.77–2.73) 0.245
TLR-10 (775 V/V)     
50–64 years 0.99 (0.73–1.36) 0.971 0.69 (0.46–1.01) 0.057
65–74 years 1.12 (0.76–1.669 0.569 0.65 (0.36–1.17) 0.149
75–85 years 1.01 (0.55–1.85) 0.98 1.11 (0.58–2.13) 0.763
  1. Analysis was carried out by univariate logistic regression comparing the less functional homozygote genotype with the others in different age groups. The reference were 19–49 years old subjects (male: n = 910, female: n = 727) and the wild type + heterozygous genotype. Significant P-values below 0.05 were printed in bold