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Table 2 Univariate and multiple regression analyses

From: Leptin, IL-6, and suPAR reflect distinct inflammatory changes associated with adiposity, lipodystrophy and low muscle mass in HIV-infected patients and controls

 

Univariate % Estimate (p)

Multiple % Estimate (p)

 

Leptin

IL-6

suPAR

Leptin

IL-6

suPAR

Age (years)

0.9 (0.45)

0.5 (0.53)

0.6 (0.05)

0.01 (1.0)

0.4 (0.64)

0.5 (0.10)

Daily smoking

−39.5 (0.06)

65.8 (0.004)

33.6 (<0.001)

−32.8 (0.13)

63.6 (0.007)

36.7 (<0.001)

Atrophy vs. Non-Lipo

−60.0 (0.007)

−17.8 (0.41)

−11.2 (0.24)

−5.1 (0.82)

6.2 (0.81)

−5.1 (0.57)

Hyper/Mix vs. Non-Lipo

104.5 (0.02)

−0.1 (0.99)

6.6 (0.47)

128.3 (<0.001)

3.3 (0.87)

3.4 (0.63)

Non-Lipo vs. Controls

16.4 (0.59)

58.3 (0.03)

23.2 (0.02)

1.6 (0.93)

27.4 (0.21)

9.9 (0.17)

FMI (kg/m2)

35.3 (<0.001)

8.0 (0.009)

0.1 (0.95)

33.5 (<0.001)

15.1 (<0.001)

3.5 (0.006)

VAT (cm2)

0.9 (<0.001)

0.3 (0.001)

0.1 (0.19)

0.8 (<0.001)

0.5 (<0.001)

0.1 (0.009)

tLMI (kg/m2)

26.4 (<0.001)

−1.3 (0.70)

−3.0 (0.03)

0.2 (0.95)

−10.8 (0.003)

−5.5 (0.002)

lLMI (kg/m2)

76.6 (<0.001)

−4.9 (0.61)

−10.6 (0.003)

−0.6 (0.95)

−20.7 (0.03)

−12.7 (<0.001)

  1. Biomarker levels were transformed using log2(x) in univariate and multiple analyses. Results are therefore back-transformed using (1-2β)*100 and shown as percent estimates per unit increase. Associations where p <0.05 are bold
  2. Abbreviations: BMI body mass index, FMI fat mass index, tLMI total lean mass index, lLMI leg lean mass index, VAT visceral adipose tissue
  3. Multiple analyses adjustments: Age was adjusted for group. Daily smoking was adjusted for age and group. Group analyses were adjusted for age, smoking, FMI, and lLMI. FMI and VAT analyses were adjusted for age, smoking, group, and lLMI. tLMI and lLMI analyses were adjusted for age, smoking, group, and FMI