Fig. 1

Weight course. Male Wistar rats were fed ad libitum with either a diet containing 25 en% (SD, open circle) or 45 en% (HFD, closed circle) of neutral fat. The diet was switched from ad libitum to a weight sustaining regimen from the age of 12 months onwards. Each animal is represented by one dot. Survival rates are given as percentage (number of animals at respective timepoint/number of young animals). Long solid line represents the group mean. Error bars represent the S.E.M. ANOVA for repeated measurement was used to determine differences between groups. Young: 2 month, middle aged: 6–12 month, old: 18–24 month