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Table 1 The clinical characteristics of the subjects with CMV seropositivity

From: Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing

Category Elderly group Adult group
Old-old Middle-old Adult-old
Number 6 7 8 8
Age 90.5 ± 2.4 79.6 ± 2.5 69.3 ± 3.1 32.0 ± 4.6
Gender (male vs female) 3vs3 4vs3 4vs4 4vs4
Number of chronic diseasesa 3.4 3.0 2.9 0
Number of daily medications(NNTs)b 5.6 5.3 5.1 0
Numbers of white blood cell(109 L−1) 7.14 ± 3.67 7.09 ± 3.56 7.20 ± 2.98 7.98 ± 3.52
Numbers of PBMC(109 L−1) 0.44 ± 0.25 0.43 ± 0.26 0.44 ± 0.24 0.48 ± 0.21
Numbers of CD8(+)(109 L−1) 0.26 ± 0.14 0.23 ± 0.12 0.25 ± 0.15 0.24 ± 0.11
Percentage ratio of CD28(+)/CD28(-) 43.4 ± 22.1/56.6 ± 33.5 49.1 ± 26.5/57.1 ± 37.8 46.9 ± 22.1/53.1 ± 39.0 55.1 ± 29.2/42.6 ± 29.3
C-reactive Protein(mg L−1) 6.39 ± 2.86 6.26 ± 3.02 6.41 ± 3.27 5.22 ± 1.45
  1. aNumber of chronic disease (multimorbidity) was calculated using 10 age-related/chronic diseases including sustained/primary hypertension, primary hyperlipidemia, type 2 diabetes, coronary atherosclerotic heart disease, chronic atrial fibrillation, preclinical valvular disease, preclinical chronic obstructive pulmonary disease, subclinical chronic liver disease, subclinical chronic renal disease, subclinical thyroid disease and long-term(subclinical > 5 years) tumor survivor
  2. bNumber of daily medications were calculated by the number of drugs necessary to treat (NNTs). It was calculatedusing15 categories of pharmaceutical administration,including:5 oral antihypertensive drugs (angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, calcium channel blockers, beta-receptor blockers, and hydrochlorothiazide); 4 oral hypoglycemic drugs (sulfonylureas, metformin, glucosidase inhibitors, and thiazolidinediones); insulin or insulin analogues; 2 lipid lowering drugs(statin and fibrate); aspirin; clopidogrel; trimetazidine; CoenzymeQ10; and isosorbidemononitrate sustained-release capsules