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Table 1 The clinical characteristics of the subjects with CMV seropositivity

From: Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing

Category

Elderly group

Adult group

Old-old

Middle-old

Adult-old

Number

6

7

8

8

Age

90.5 ± 2.4

79.6 ± 2.5

69.3 ± 3.1

32.0 ± 4.6

Gender (male vs female)

3vs3

4vs3

4vs4

4vs4

Number of chronic diseasesa

3.4

3.0

2.9

0

Number of daily medications(NNTs)b

5.6

5.3

5.1

0

Numbers of white blood cell(109 L−1)

7.14 ± 3.67

7.09 ± 3.56

7.20 ± 2.98

7.98 ± 3.52

Numbers of PBMC(109 L−1)

0.44 ± 0.25

0.43 ± 0.26

0.44 ± 0.24

0.48 ± 0.21

Numbers of CD8(+)(109 L−1)

0.26 ± 0.14

0.23 ± 0.12

0.25 ± 0.15

0.24 ± 0.11

Percentage ratio of CD28(+)/CD28(-)

43.4 ± 22.1/56.6 ± 33.5

49.1 ± 26.5/57.1 ± 37.8

46.9 ± 22.1/53.1 ± 39.0

55.1 ± 29.2/42.6 ± 29.3

C-reactive Protein(mg L−1)

6.39 ± 2.86

6.26 ± 3.02

6.41 ± 3.27

5.22 ± 1.45

  1. aNumber of chronic disease (multimorbidity) was calculated using 10 age-related/chronic diseases including sustained/primary hypertension, primary hyperlipidemia, type 2 diabetes, coronary atherosclerotic heart disease, chronic atrial fibrillation, preclinical valvular disease, preclinical chronic obstructive pulmonary disease, subclinical chronic liver disease, subclinical chronic renal disease, subclinical thyroid disease and long-term(subclinical > 5 years) tumor survivor
  2. bNumber of daily medications were calculated by the number of drugs necessary to treat (NNTs). It was calculatedusing15 categories of pharmaceutical administration,including:5 oral antihypertensive drugs (angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, calcium channel blockers, beta-receptor blockers, and hydrochlorothiazide); 4 oral hypoglycemic drugs (sulfonylureas, metformin, glucosidase inhibitors, and thiazolidinediones); insulin or insulin analogues; 2 lipid lowering drugs(statin and fibrate); aspirin; clopidogrel; trimetazidine; CoenzymeQ10; and isosorbidemononitrate sustained-release capsules