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Fig. 3 | Immunity & Ageing

Fig. 3

From: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies

Fig. 3

Anti-neo-epitope IgMs are present in the serum from other species than mice. Representative images of the hippocampal region of brain sections from 12-month-old ICR-CD1 mice simultaneously stained with Hoechst (blue), anti-MMP-2 antibody and rabbit (a), rat (b) and goat (c) serum. Clusters of granules can be observed with the anti-MMP-2 staining (red in a and c and green in b) and some granules of the clusters are stained with the different sera (green in a and c and red in b), which indicates that the serum of these species contained anti-neo-epitope IgMs. Scale bar: 50 μm

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Immunity & Ageing

ISSN: 1742-4933

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