Fig. 4

Anti-neo-epitope IgMs are auto-antibodies. Representative images of the hippocampal region of brain sections from different mice stained with their own serum (red) and both the anti-MMP2 antibody (green) and Hoechst (blue). a-c: Representative ICR-CD1 mice aged 3, 6 and 9 months, respectively. d-f: Representative SAMP8 mice aged 3 and 6 months. As can be observed, the granules are stained by the serum of the own mouse. Thus, each serum recognize the own neo-epitope present in its clusters of granules. Scale bar: 50 μm