End stage renal disease patients have a skewed T cell receptor Vβ repertoire

Immunity & Ageing

Table 2 The variables related to a skewed TCR Vβ repertoire

	Non-skewed TCR Vβ	Skewed TCR Vβ	Odds ratio	P value
Age (years, median)	41	65	3.1^a	< 0.05
% of CMV seropositivity	30.7	74.5	13.8^b	< 0.05
% of ESRD patients	28.6	70.0	10.2^c	< 0.05
% of patients on renal replacement therapy	35.8	48.4		NS
Underlying kidney disease (number)
Nephrosclerosis/atherosclerosis/hypertensive nephropathy	1	7		NS
Primary glomerulopathy	0	3		NS
Diabetic nephropathy	2	7		NS
Reflux nephropathy	4	4		NS
Polycystic kidney disease	2	7		NS
Other	5	2
Unknown	0	1

Abbreviations: TCR T cell receptor, NS not significant
^ameans the odds of a skewed TCR Vβ repertoire in elderly population is 3.1 times higher than in the young population
^bmeans the odds of a skewed TCR Vβ repertoire in CMV- IgG seropositive population is 13.8 times higher than in the CMV- IgG seronegative population
^Cmeans the odds of a skewed TCR Vβ repertoire in patients is 10.2 times higher than in the healthy individuals

ISSN: 1742-4933