Fig. 4

The T cell response to the immunodominant CMV protein pp65 increases with age. T cells were stimulated with peptide pools containing either pp65 or IE-1 and the IFN-g release by peptide-specific CD4 and CD8 T cells was then determined. a Representation of the flow plots for IFN-g response to pp65 and IE-1 peptide stimulation. b Correlation of the T cell response to IE-1 peptides against age demonstrated a peak in people aged 50–60 years followed by a decreased response in older donors. The CD4+ T cell response to IE-1 peptide was small but remained relatively constant across all ages. c Both CD4 and CD8 T cell response to pp65 increase with ageing