Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration

Table 2 C3a, C4a and C5a plasma levels in nAMD patients and controls

			Univariate analysis	Multivariate analysis (age and gender)			Multivariate analysis (age, gender and family history of AMD)
Variables (ng/ml)	Controls (mean ± SD) n = 43	nAMD (mean ± SD) n = 96	P value nAMD vs Controls^a	P value nAMD vs Controls^b	Odds ratio	95 % confidence interval for odds ratio	P value nAMD vs Controls^c	Odds ratio	95 % confidence interval for odds ratio
C3a	11.95 ± 3.30	14.65 ± 4.48	<0.001	0.001	241.44	8.44–6910.14	0.005	140.67	4.53–4372.57
C4a	68.91 ± 33.23	108.48 ± 83.83	0.005	0.012	5.81	1.46–23.05	0.031	4.79	1.15–19.88
C5a	8.34 ± 2.05	9.43 ± 2.73	0.049	0.045	20.55	1.07–396.06

^aIndependent samples t-test
^bMultinomial logistic regression corrected for age and gender
^cMultinomial logistic regression corrected for age, gender and family history of AMD
Bold P < 0.05
SD standard deviation

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