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Table 2 Effect of B. longum + Gl-OS on seroprotection status in young and older subjects before and 4 weeks after influenza vaccination

From: Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence

 

Seroprotection status

 

Vaccine strain

 

Young cohort (n = 58)

Older cohort (n = 54)

p

  

Placebo

B. longum + Gl-OS

Placebo

B. longum + Gl-OS

 
  

n/N (%)

n/N (%)

n/N (%)

n/N (%)

 

A/California/7/2009 (H1N1)

Before

20/29 (69)a

13/29 (45)a

5/28 (18)

1/26 (4)

< 0.001

After

29/29 (100)

27/29 (93)a

22/27 (81)

16/26 (62)

< 0.001

A/Perth/16/2009 (H3N2)

Before

10/29 (34)

13/29 (45)

8/28 (29)

12/26 (46)

NS

After

26/29 (90)

27/29 (93)

25/27 (93)

22/26 (85)

NS

B/Brisbane/60/2008

Before

4/29 (14)

0/29 (0)

4/24 (17)

5/26 (19)

NS

After

28/29 (97)

20/29 (76)

14/27 (52)

11/26 (42)

< 0.001

  1. Data are numbers of seroprotected (n)/total (N) and % seroprotected subjects in parentheses. ‘Before’ refers to week 4 samples and ‘After’ refers to week 8 samples (ie 4 weeks after vaccination). P refers to results of Fisher’s exact test for differences between the cohorts with treatment groups combined; ayoung cohort significantly different from the older cohort within same treatment group (p < 0.01, Fisher’s Exact test)
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Immunity & Ageing

ISSN: 1742-4933

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