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Table 2 Effect of B. longum + Gl-OS on seroprotection status in young and older subjects before and 4 weeks after influenza vaccination

From: Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence

  Seroprotection status  
Vaccine strain   Young cohort (n = 58) Older cohort (n = 54) p
   Placebo B. longum + Gl-OS Placebo B. longum + Gl-OS  
   n/N (%) n/N (%) n/N (%) n/N (%)  
A/California/7/2009 (H1N1) Before 20/29 (69)a 13/29 (45)a 5/28 (18) 1/26 (4) < 0.001
After 29/29 (100) 27/29 (93)a 22/27 (81) 16/26 (62) < 0.001
A/Perth/16/2009 (H3N2) Before 10/29 (34) 13/29 (45) 8/28 (29) 12/26 (46) NS
After 26/29 (90) 27/29 (93) 25/27 (93) 22/26 (85) NS
B/Brisbane/60/2008 Before 4/29 (14) 0/29 (0) 4/24 (17) 5/26 (19) NS
After 28/29 (97) 20/29 (76) 14/27 (52) 11/26 (42) < 0.001
  1. Data are numbers of seroprotected (n)/total (N) and % seroprotected subjects in parentheses. ‘Before’ refers to week 4 samples and ‘After’ refers to week 8 samples (ie 4 weeks after vaccination). P refers to results of Fisher’s exact test for differences between the cohorts with treatment groups combined; ayoung cohort significantly different from the older cohort within same treatment group (p < 0.01, Fisher’s Exact test)