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Table 3 Effect of B. longum + Gl-OS on seroconversion in young and older subjects 4 weeks after influenza vaccination (week 8)

From: Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence

  Seroconversion status (≥ fourfold increase in Ab titres)  
Vaccine strain Young cohort (n = 58) Older cohort (n = 54) p
  Placebo B. longum + Gl-OS Placebo B. longum + Gl-OS  
  n/N (%) n/N (%) n/N (%) n/N (%)  
A/California/7/2009 (H1N1) 15/29 (52) 18/29 (62) 21/27 (78) 15/26 (58) NS
A/Perth/16/2009 (H3N2) 20/29 (69) 22/29 (76)a 17/27 (63) 10/26 (38) 0.031
B/Brisbane/60/2008 23/29 (79)a 20/29 (69)a 7/27 (26) 1/26 (4) < 0.001
  1. Data are numbers of seroconverted (n)/total (N) and % seroconverted subjects in parentheses. P refers to results of Fisher’s exact test for differences between the cohorts with treatment groups combined; ayoung cohort significantly different from the older cohort within same treatment group (p < 0.01, Fisher’s Exact test)