From: Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study
 | IL-6 [pg/mL] | CRP [mg/L] | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alla | Successfully agingb | Othersc | Alla | Successfully agingb | Othersc | ||||||||
n | Concentrationd | n | Concentrationd | n | Concentrationd | n | Concentrationd | n | Concentrationd | n | Concentrationd | ||
BMI [kg/m2] | <18.5 | 60 | 3.2 [1.8, 5.4] | 21 | 3.2 [1.7, 4.8] | 39 | 3.2 [1.9, 5.7] | 64 | 2.3 [1.0, 7.4] | 21 | 1.8 [0.7, 7.5] | 43 | 2.5 [1.0, 7.2] |
18.5-24.9 | 814 | 2.3 [1.4, 3.9] | 315 | 1.9 [1.2, 3.2] | 499 | 2.5 [1.6, 4.5] | 865 | 1.7 [0.8, 3.8] | 336 | 1.5 [0.8, 3.0] | 529 | 1.8 [0.9, 4.3] | |
25–29.9 | 1381 | 2.2 [1.4, 3.5] | 548 | 1.9 [1.3, 3.2] | 833 | 2.3 [1.5, 3.8] | 1425 | 2.1 [1.0, 4.2] | 569 | 2.0 [1.0, 4.0] | 856 | 2.2 [1.0, 4.3] | |
30–39.9 | 997 | 2.3 [1.6, 3.6] | 343 | 2.2 [1.4, 3.6] | 654 | 2.4 [1.7, 3.6] | 1025 | 2.8 [1.5, 5.2] | 354 | 2.9 [1.6, 5.4] | 671 | 2.7 [1.4, 5.1] | |
≥40 | 69 | 2.8 [2.1, 4.1] | 17 | 2.5 [1.9, 3.4] | 52 | 2.9 [2.1, 4.9] | 69 | 4.2 [2.2, 8.8] | 17 | 4.3 [2.5, 7.8] | 52 | 4.1 [2.1, 9.1] | |
Cholesterol [mg/dL] | <175 | 1029 | 2.7 [1.7, 4.8] | 256 | 2.4 [1.5, 4.4] | 773 | 2.8 [1.8, 5.1] | 1085 | 2.3 [1.0, 5.3] | 267 | 2.2 [1.0, 5.0] | 818 | 2.4 [1.0, 5.3] |
175–189 | 452 | 2.3 [1.6, 3.8] | 178 | 2.2 [1.4, 3.7] | 274 | 2.4 [1.7, 3.8] | 478 | 2.4 [1.1, 5.1] | 184 | 1.9 [1.0, 4.2] | 294 | 2.6 [1.1, 5.7] | |
190–239 | 1302 | 2.2 [1.5, 3.5] | 512 | 2.0 [1.3, 3.1] | 790 | 2.4 [1.6, 3.8] | 1375 | 2.2 [1.1, 4.4] | 543 | 2.2 [1.0, 4.1] | 832 | 2.3 [1.1, 4.7] | |
240–309 | 593 | 2.0 [1.4, 3.1] | 275 | 1.8 [1.2, 2.7] | 318 | 2.2 [1.5, 3.4] | 627 | 2.3 [1.2, 4.5] | 291 | 2.1 [1.2, 4.0] | 336 | 2.7 [1.4, 5.2] | |
≥310 | 65 | 2.2 [1.4, 3.6] | 27 | 2.4 [1.4, 3.7] | 38 | 2.2 [1.5, 3.6] | 67 | 3.3 [1.5, 5.2] | 27 | 2.1 [1.0, 5.0] | 40 | 3.6 [1.7, 5.3] | |
HDL [mg/dL] | <40 | 774 | 3.0 [1.8, 4.9] | 199 | 2.7 [1.6, 3.9] | 575 | 3.1 [1.9, 5.3] | 822 | 2.9 [1.4, 6.2] | 211 | 2.6 [1.3, 5.4] | 611 | 3.0 [1.5, 6.5] |
40–44 | 525 | 2.6 [1.7, 4.4] | 168 | 2.4 [1.6, 4.0] | 357 | 2.7 [1.8, 4.5] | 549 | 2.4 [1.2, 5.0] | 176 | 2.3 [1.3, 4.7] | 373 | 2.4 [1.2, 5.1] | |
45–49 | 528 | 2.4 [1.6, 4.0] | 190 | 2.1 [1.3, 3.5] | 338 | 2.6 [1.8, 4.2] | 549 | 2.5 [1.1, 5.3] | 201 | 2.5 [1.1, 4.8] | 348 | 2.4 [1.2, 5.9] | |
50–59 | 851 | 2.1 [1.4, 3.4] | 362 | 1.9 [1.3, 3.2] | 489 | 2.2 [1.5, 3.4] | 900 | 2.2 [1.1, 4.2] | 370 | 2.1 [1.0, 3.9] | 530 | 2.3 [1.1, 4.3] | |
≥60 | 760 | 1.8 [1.2, 3.0] | 328 | 1.7 [1.1, 2.6] | 432 | 2.0 [1.3, 3.3] | 810 | 1.8 [0.8, 3.6] | 353 | 1.6 [0.8, 3.1] | 457 | 1.9 [0.9, 4.1] | |
LDL [mg/dL] | <70 | 329 | 2.8 [1.8, 5.1] | 53 | 2.2 [1.6, 3.6] | 276 | 2.9 [1.9, 5.5] | 347 | 2.4 [0.9, 4.9] | 55 | 2.4 [0.7, 5.0] | 292 | 2.4 [1.0, 4.9] |
71–99 | 809 | 2.5 [1.6, 4.2] | 234 | 2.2 [1.5, 4.1] | 575 | 2.6 [1.6, 4.2] | 860 | 2.3 [1.0, 4.7] | 249 | 1.9 [1.0, 4.3] | 611 | 2.4 [1.0, 5.0] | |
100–114 | 506 | 2.3 [1.6, 4.0] | 204 | 2.1 [1.3, 3.6] | 302 | 2.5 [1.7, 4.3] | 530 | 2.1 [1.0, 4.8] | 214 | 2.1 [1.0, 4.2] | 316 | 2.1 [1.0, 5.1] | |
115–154 | 1168 | 2.2 [1.4, 3.5] | 463 | 1.9 [1.3, 3.1] | 705 | 2.4 [1.6, 3.7] | 1234 | 2.2 [1.1, 4.6] | 485 | 2.1 [1.0, 4.0] | 749 | 2.5 [1.2, 5.1] | |
155–189 | 468 | 2.1 [1.5, 3.3] | 218 | 1.9 [1.3, 2.9] | 250 | 2.2 [1.6, 3.8] | 494 | 2.5 [1.4, 4.6] | 230 | 2.3 [1.2, 4.1] | 264 | 2.7 [1.5, 5.5] | |
≥190 | 159 | 2.1 [1.3, 3.2] | 75 | 1.8 [1.2, 3.0] | 84 | 2.2 [1.5, 3.4] | 166 | 2.7 [1.2, 5.4] | 78 | 2.3 [1.2, 5.4] | 88 | 3.0 [1.3, 5.4] | |
Glucose [mg/dL] | <100 | 2133 | 2.3 [1.5, 3.8] | 924 | 2.0 [1.3, 3.3] | 1209 | 2.5 [1.7, 4.4] | 2261 | 2.2 [1.0, 4.6] | 966 | 2.1 [1.0, 4.1] | 1295 | 2.4 [1.1, 5.0] |
100–139.9 | 1042 | 2.4 [1.6, 3.7] | 324 | 2.1 [1.4, 3.4] | 718 | 2.5 [1.6, 3.8] | 1089 | 2.3 [1.1, 4.8] | 346 | 2.2 [1.1, 4.8] | 743 | 2.4 [1.1, 4.9] | |
≥140 | 256 | 2.5 [1.7, 4.1] | na | na | 256 | 2.5 [1.7, 4.1] | 272 | 3.0 [1.4, 6.8] | na | na | 272 | 3.0 [1.4, 6.8] | |
eGFR [mL/min/ 1.73Â m2] | <45 | 359 | 3.2 [2.1, 5.3] | 70 | 3.8 [2.6, 6.7] | 289 | 3.0 [2.0, 5.2] | 378 | 3.2 [1.5, 6.3] | 77 | 3.5 [1.9, 6.3] | 301 | 3.0 [1.5, 6.3] |
45–60 | 639 | 2.7 [1.7, 4.1] | 187 | 2.4 [1.5, 3.6] | 452 | 2.8 [1.8, 4.5] | 668 | 2.5 [1.1, 5.4] | 192 | 2.2 [1.1, 4.4] | 476 | 2.7 [1.2, 6.2] | |
>60 | 2421 | 2.1 [1.4, 3.5] | 977 | 1.9 [1.3, 3.1] | 1444 | 2.3 [1.6, 3.8] | 2531 | 2.2 [1.0, 4.4] | 1019 | 2.0 [1.0, 4.1] | 1512 | 2.3 [1.0, 4.7] | |
Heart rate [per min] | <60 | 341 | 2.2 [1.5, 3.6] | 126 | 1.8 [1.2, 2.9] | 215 | 2.6 [1.6, 4.0] | 354 | 1.6 [0.9, 3.6] | 131 | 1.8 [1.0, 3.6] | 223 | 1.5 [0.9, 3.6] |
60–80 | 2374 | 2.2 [1.5, 3.6] | 893 | 2.0 [1.3, 3.2] | 1481 | 2.3 [1.6, 3.8] | 2463 | 2.3 [1.0, 4.5] | 929 | 2.1 [1.0, 4.0] | 1534 | 2.4 [1.1, 4.9] | |
>80 | 768 | 2.7 [1.7, 4.8] | 239 | 2.4 [1.5, 4.0] | 529 | 2.8 [1.8, 5.1] | 801 | 3.0 [1.4, 6.2] | 252 | 2.7 [1.3, 5.6] | 549 | 3.1 [1.4, 6.3] | |
Smoking | Never | 1968 | 2.3 [1.5, 3.7] | 689 | 1.9 [1.3, 3.1] | 1279 | 2.4 [1.6, 4.1] | 2035 | 2.3 [1.1, 4.5] | 710 | 2.1 [1.0, 3.9] | 1325 | 2.4 [1.1, 4.9] |
Past | 1196 | 2.4 [1.5, 3.8] | 424 | 2.0 [1.4, 3.3] | 772 | 2.5 [1.6, 4.0] | 1250 | 2.2 [1.0, 4.8] | 450 | 2.1 [1.0, 4.5] | 800 | 2.3 [1.0, 5.0] | |
Current | 304 | 2.7 [1.7, 4.5] | 140 | 2.4 [1.4, 3.7] | 164 | 3.0 [1.8, 5.2] | 319 | 3.1 [1.3, 6.2] | 147 | 2.4 [1.1, 5.1] | 172 | 3.4 [1.5, 7.7] | |
MMSE [points] | 28–30 | 1121 | 1.9 [1.3, 3.1] | 606 | 1.9 [1.2, 3.0] | 515 | 2.0 [1.4, 3.1] | 1153 | 2.0 [1.0, 4.1] | 629 | 1.9 [1.0, 4.1] | 524 | 2.1 [1.0, 4.1] |
24–27 | 1245 | 2.3 [1.5, 3.7] | 637 | 2.2 [1.4, 3.6] | 608 | 2.4 [1.6, 4.0] | 1302 | 2.3 [1.1, 4.6] | 668 | 2.3 [1.1, 4.4] | 634 | 2.5 [1.1, 5.1] | |
20–23 | 593 | 2.6 [1.7, 4.3] | na | na | 593 | 2.6 [1.7, 4.3] | 617 | 2.4 [1.2, 5.2] | na | na | 617 | 2.4 [1.2, 5.2] | |
10–19 | 324 | 3.0 [2.0, 5.5] | na | na | 324 | 3.0 [2.0, 5.5] | 348 | 2.5 [1.0, 5.4] | na | na | 348 | 2.5 [1.0, 5.4] | |
<10 | 111 | 3.3 [2.1, 6.0] | na | na | 111 | 3.3 [2.1, 6.0] | 114 | 3.7 [1.5, 8.3] | na | na | 114 | 3.7 [1.5, 8.3] | |
ADL [points] | 5–6 | 3112 | 2.2 [1.5, 3.6] | 1258 | 2.0 [1.3, 3.3] | 1854 | 2.3 [1.6, 3.7] | 3220 | 2.2 [1.0, 4.4] | 1312 | 2.1 [1.0, 4.3] | 1908 | 2.2 [1.0, 4.5] |
3–4 | 205 | 3.2 [2.2, 6.2] | na | na | 205 | 3.2 [2.2, 6.2] | 220 | 3.4 [1.7, 9.3] | na | na | 220 | 3.4 [1.7, 9.3] | |
0–2 | 165 | 4.2 [2.6, 7.4] | na | na | 165 | 4.2 [2.6, 7.4] | 178 | 3.9 [1.9, 9.4] | na | na | 178 | 3.9 [1.9, 9.4] |