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Table 2 IL-6 and CRP concentration in ≥65 year-old seniors in relation to select clinical and biochemical parameters, and functional status

From: Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

 

IL-6 [pg/mL]

CRP [mg/L]

Alla

Successfully agingb

Othersc

Alla

Successfully agingb

Othersc

n

Concentrationd

n

Concentrationd

n

Concentrationd

n

Concentrationd

n

Concentrationd

n

Concentrationd

BMI [kg/m2]

<18.5

60

3.2 [1.8, 5.4]

21

3.2 [1.7, 4.8]

39

3.2 [1.9, 5.7]

64

2.3 [1.0, 7.4]

21

1.8 [0.7, 7.5]

43

2.5 [1.0, 7.2]

18.5-24.9

814

2.3 [1.4, 3.9]

315

1.9 [1.2, 3.2]

499

2.5 [1.6, 4.5]

865

1.7 [0.8, 3.8]

336

1.5 [0.8, 3.0]

529

1.8 [0.9, 4.3]

25–29.9

1381

2.2 [1.4, 3.5]

548

1.9 [1.3, 3.2]

833

2.3 [1.5, 3.8]

1425

2.1 [1.0, 4.2]

569

2.0 [1.0, 4.0]

856

2.2 [1.0, 4.3]

30–39.9

997

2.3 [1.6, 3.6]

343

2.2 [1.4, 3.6]

654

2.4 [1.7, 3.6]

1025

2.8 [1.5, 5.2]

354

2.9 [1.6, 5.4]

671

2.7 [1.4, 5.1]

≥40

69

2.8 [2.1, 4.1]

17

2.5 [1.9, 3.4]

52

2.9 [2.1, 4.9]

69

4.2 [2.2, 8.8]

17

4.3 [2.5, 7.8]

52

4.1 [2.1, 9.1]

Cholesterol [mg/dL]

<175

1029

2.7 [1.7, 4.8]

256

2.4 [1.5, 4.4]

773

2.8 [1.8, 5.1]

1085

2.3 [1.0, 5.3]

267

2.2 [1.0, 5.0]

818

2.4 [1.0, 5.3]

175–189

452

2.3 [1.6, 3.8]

178

2.2 [1.4, 3.7]

274

2.4 [1.7, 3.8]

478

2.4 [1.1, 5.1]

184

1.9 [1.0, 4.2]

294

2.6 [1.1, 5.7]

190–239

1302

2.2 [1.5, 3.5]

512

2.0 [1.3, 3.1]

790

2.4 [1.6, 3.8]

1375

2.2 [1.1, 4.4]

543

2.2 [1.0, 4.1]

832

2.3 [1.1, 4.7]

240–309

593

2.0 [1.4, 3.1]

275

1.8 [1.2, 2.7]

318

2.2 [1.5, 3.4]

627

2.3 [1.2, 4.5]

291

2.1 [1.2, 4.0]

336

2.7 [1.4, 5.2]

≥310

65

2.2 [1.4, 3.6]

27

2.4 [1.4, 3.7]

38

2.2 [1.5, 3.6]

67

3.3 [1.5, 5.2]

27

2.1 [1.0, 5.0]

40

3.6 [1.7, 5.3]

HDL [mg/dL]

<40

774

3.0 [1.8, 4.9]

199

2.7 [1.6, 3.9]

575

3.1 [1.9, 5.3]

822

2.9 [1.4, 6.2]

211

2.6 [1.3, 5.4]

611

3.0 [1.5, 6.5]

40–44

525

2.6 [1.7, 4.4]

168

2.4 [1.6, 4.0]

357

2.7 [1.8, 4.5]

549

2.4 [1.2, 5.0]

176

2.3 [1.3, 4.7]

373

2.4 [1.2, 5.1]

45–49

528

2.4 [1.6, 4.0]

190

2.1 [1.3, 3.5]

338

2.6 [1.8, 4.2]

549

2.5 [1.1, 5.3]

201

2.5 [1.1, 4.8]

348

2.4 [1.2, 5.9]

50–59

851

2.1 [1.4, 3.4]

362

1.9 [1.3, 3.2]

489

2.2 [1.5, 3.4]

900

2.2 [1.1, 4.2]

370

2.1 [1.0, 3.9]

530

2.3 [1.1, 4.3]

≥60

760

1.8 [1.2, 3.0]

328

1.7 [1.1, 2.6]

432

2.0 [1.3, 3.3]

810

1.8 [0.8, 3.6]

353

1.6 [0.8, 3.1]

457

1.9 [0.9, 4.1]

LDL [mg/dL]

<70

329

2.8 [1.8, 5.1]

53

2.2 [1.6, 3.6]

276

2.9 [1.9, 5.5]

347

2.4 [0.9, 4.9]

55

2.4 [0.7, 5.0]

292

2.4 [1.0, 4.9]

71–99

809

2.5 [1.6, 4.2]

234

2.2 [1.5, 4.1]

575

2.6 [1.6, 4.2]

860

2.3 [1.0, 4.7]

249

1.9 [1.0, 4.3]

611

2.4 [1.0, 5.0]

100–114

506

2.3 [1.6, 4.0]

204

2.1 [1.3, 3.6]

302

2.5 [1.7, 4.3]

530

2.1 [1.0, 4.8]

214

2.1 [1.0, 4.2]

316

2.1 [1.0, 5.1]

115–154

1168

2.2 [1.4, 3.5]

463

1.9 [1.3, 3.1]

705

2.4 [1.6, 3.7]

1234

2.2 [1.1, 4.6]

485

2.1 [1.0, 4.0]

749

2.5 [1.2, 5.1]

155–189

468

2.1 [1.5, 3.3]

218

1.9 [1.3, 2.9]

250

2.2 [1.6, 3.8]

494

2.5 [1.4, 4.6]

230

2.3 [1.2, 4.1]

264

2.7 [1.5, 5.5]

≥190

159

2.1 [1.3, 3.2]

75

1.8 [1.2, 3.0]

84

2.2 [1.5, 3.4]

166

2.7 [1.2, 5.4]

78

2.3 [1.2, 5.4]

88

3.0 [1.3, 5.4]

Glucose [mg/dL]

<100

2133

2.3 [1.5, 3.8]

924

2.0 [1.3, 3.3]

1209

2.5 [1.7, 4.4]

2261

2.2 [1.0, 4.6]

966

2.1 [1.0, 4.1]

1295

2.4 [1.1, 5.0]

100–139.9

1042

2.4 [1.6, 3.7]

324

2.1 [1.4, 3.4]

718

2.5 [1.6, 3.8]

1089

2.3 [1.1, 4.8]

346

2.2 [1.1, 4.8]

743

2.4 [1.1, 4.9]

≥140

256

2.5 [1.7, 4.1]

na

na

256

2.5 [1.7, 4.1]

272

3.0 [1.4, 6.8]

na

na

272

3.0 [1.4, 6.8]

eGFR [mL/min/ 1.73 m2]

<45

359

3.2 [2.1, 5.3]

70

3.8 [2.6, 6.7]

289

3.0 [2.0, 5.2]

378

3.2 [1.5, 6.3]

77

3.5 [1.9, 6.3]

301

3.0 [1.5, 6.3]

45–60

639

2.7 [1.7, 4.1]

187

2.4 [1.5, 3.6]

452

2.8 [1.8, 4.5]

668

2.5 [1.1, 5.4]

192

2.2 [1.1, 4.4]

476

2.7 [1.2, 6.2]

>60

2421

2.1 [1.4, 3.5]

977

1.9 [1.3, 3.1]

1444

2.3 [1.6, 3.8]

2531

2.2 [1.0, 4.4]

1019

2.0 [1.0, 4.1]

1512

2.3 [1.0, 4.7]

Heart rate [per min]

<60

341

2.2 [1.5, 3.6]

126

1.8 [1.2, 2.9]

215

2.6 [1.6, 4.0]

354

1.6 [0.9, 3.6]

131

1.8 [1.0, 3.6]

223

1.5 [0.9, 3.6]

60–80

2374

2.2 [1.5, 3.6]

893

2.0 [1.3, 3.2]

1481

2.3 [1.6, 3.8]

2463

2.3 [1.0, 4.5]

929

2.1 [1.0, 4.0]

1534

2.4 [1.1, 4.9]

>80

768

2.7 [1.7, 4.8]

239

2.4 [1.5, 4.0]

529

2.8 [1.8, 5.1]

801

3.0 [1.4, 6.2]

252

2.7 [1.3, 5.6]

549

3.1 [1.4, 6.3]

Smoking

Never

1968

2.3 [1.5, 3.7]

689

1.9 [1.3, 3.1]

1279

2.4 [1.6, 4.1]

2035

2.3 [1.1, 4.5]

710

2.1 [1.0, 3.9]

1325

2.4 [1.1, 4.9]

Past

1196

2.4 [1.5, 3.8]

424

2.0 [1.4, 3.3]

772

2.5 [1.6, 4.0]

1250

2.2 [1.0, 4.8]

450

2.1 [1.0, 4.5]

800

2.3 [1.0, 5.0]

Current

304

2.7 [1.7, 4.5]

140

2.4 [1.4, 3.7]

164

3.0 [1.8, 5.2]

319

3.1 [1.3, 6.2]

147

2.4 [1.1, 5.1]

172

3.4 [1.5, 7.7]

MMSE [points]

28–30

1121

1.9 [1.3, 3.1]

606

1.9 [1.2, 3.0]

515

2.0 [1.4, 3.1]

1153

2.0 [1.0, 4.1]

629

1.9 [1.0, 4.1]

524

2.1 [1.0, 4.1]

24–27

1245

2.3 [1.5, 3.7]

637

2.2 [1.4, 3.6]

608

2.4 [1.6, 4.0]

1302

2.3 [1.1, 4.6]

668

2.3 [1.1, 4.4]

634

2.5 [1.1, 5.1]

20–23

593

2.6 [1.7, 4.3]

na

na

593

2.6 [1.7, 4.3]

617

2.4 [1.2, 5.2]

na

na

617

2.4 [1.2, 5.2]

10–19

324

3.0 [2.0, 5.5]

na

na

324

3.0 [2.0, 5.5]

348

2.5 [1.0, 5.4]

na

na

348

2.5 [1.0, 5.4]

<10

111

3.3 [2.1, 6.0]

na

na

111

3.3 [2.1, 6.0]

114

3.7 [1.5, 8.3]

na

na

114

3.7 [1.5, 8.3]

ADL [points]

5–6

3112

2.2 [1.5, 3.6]

1258

2.0 [1.3, 3.3]

1854

2.3 [1.6, 3.7]

3220

2.2 [1.0, 4.4]

1312

2.1 [1.0, 4.3]

1908

2.2 [1.0, 4.5]

3–4

205

3.2 [2.2, 6.2]

na

na

205

3.2 [2.2, 6.2]

220

3.4 [1.7, 9.3]

na

na

220

3.4 [1.7, 9.3]

0–2

165

4.2 [2.6, 7.4]

na

na

165

4.2 [2.6, 7.4]

178

3.9 [1.9, 9.4]

na

na

178

3.9 [1.9, 9.4]

  1. a: Excluded are individuals with leukocytosis exceeding 10,000/mm3 or treated with glucocorticoids
  2. b: Only individuals without past or current cancer, type 2 diabetes, cardiovascular disease/myocardial infarction/stroke, and with the MMSE score ≥24 and the ADL score 5–6
  3. c: Individuals who did not meet the definition of successful aging
  4. d: Concentrations of IL–6 and CRP are shown as median [1st quartile, 3rd quartile]
  5. n Number of individuals
  6. na Not applicable