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Table 2 IL-6 and CRP concentration in ≥65 year-old seniors in relation to select clinical and biochemical parameters, and functional status

From: Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

  IL-6 [pg/mL] CRP [mg/L]
Alla Successfully agingb Othersc Alla Successfully agingb Othersc
n Concentrationd n Concentrationd n Concentrationd n Concentrationd n Concentrationd n Concentrationd
BMI [kg/m2] <18.5 60 3.2 [1.8, 5.4] 21 3.2 [1.7, 4.8] 39 3.2 [1.9, 5.7] 64 2.3 [1.0, 7.4] 21 1.8 [0.7, 7.5] 43 2.5 [1.0, 7.2]
18.5-24.9 814 2.3 [1.4, 3.9] 315 1.9 [1.2, 3.2] 499 2.5 [1.6, 4.5] 865 1.7 [0.8, 3.8] 336 1.5 [0.8, 3.0] 529 1.8 [0.9, 4.3]
25–29.9 1381 2.2 [1.4, 3.5] 548 1.9 [1.3, 3.2] 833 2.3 [1.5, 3.8] 1425 2.1 [1.0, 4.2] 569 2.0 [1.0, 4.0] 856 2.2 [1.0, 4.3]
30–39.9 997 2.3 [1.6, 3.6] 343 2.2 [1.4, 3.6] 654 2.4 [1.7, 3.6] 1025 2.8 [1.5, 5.2] 354 2.9 [1.6, 5.4] 671 2.7 [1.4, 5.1]
≥40 69 2.8 [2.1, 4.1] 17 2.5 [1.9, 3.4] 52 2.9 [2.1, 4.9] 69 4.2 [2.2, 8.8] 17 4.3 [2.5, 7.8] 52 4.1 [2.1, 9.1]
Cholesterol [mg/dL] <175 1029 2.7 [1.7, 4.8] 256 2.4 [1.5, 4.4] 773 2.8 [1.8, 5.1] 1085 2.3 [1.0, 5.3] 267 2.2 [1.0, 5.0] 818 2.4 [1.0, 5.3]
175–189 452 2.3 [1.6, 3.8] 178 2.2 [1.4, 3.7] 274 2.4 [1.7, 3.8] 478 2.4 [1.1, 5.1] 184 1.9 [1.0, 4.2] 294 2.6 [1.1, 5.7]
190–239 1302 2.2 [1.5, 3.5] 512 2.0 [1.3, 3.1] 790 2.4 [1.6, 3.8] 1375 2.2 [1.1, 4.4] 543 2.2 [1.0, 4.1] 832 2.3 [1.1, 4.7]
240–309 593 2.0 [1.4, 3.1] 275 1.8 [1.2, 2.7] 318 2.2 [1.5, 3.4] 627 2.3 [1.2, 4.5] 291 2.1 [1.2, 4.0] 336 2.7 [1.4, 5.2]
≥310 65 2.2 [1.4, 3.6] 27 2.4 [1.4, 3.7] 38 2.2 [1.5, 3.6] 67 3.3 [1.5, 5.2] 27 2.1 [1.0, 5.0] 40 3.6 [1.7, 5.3]
HDL [mg/dL] <40 774 3.0 [1.8, 4.9] 199 2.7 [1.6, 3.9] 575 3.1 [1.9, 5.3] 822 2.9 [1.4, 6.2] 211 2.6 [1.3, 5.4] 611 3.0 [1.5, 6.5]
40–44 525 2.6 [1.7, 4.4] 168 2.4 [1.6, 4.0] 357 2.7 [1.8, 4.5] 549 2.4 [1.2, 5.0] 176 2.3 [1.3, 4.7] 373 2.4 [1.2, 5.1]
45–49 528 2.4 [1.6, 4.0] 190 2.1 [1.3, 3.5] 338 2.6 [1.8, 4.2] 549 2.5 [1.1, 5.3] 201 2.5 [1.1, 4.8] 348 2.4 [1.2, 5.9]
50–59 851 2.1 [1.4, 3.4] 362 1.9 [1.3, 3.2] 489 2.2 [1.5, 3.4] 900 2.2 [1.1, 4.2] 370 2.1 [1.0, 3.9] 530 2.3 [1.1, 4.3]
≥60 760 1.8 [1.2, 3.0] 328 1.7 [1.1, 2.6] 432 2.0 [1.3, 3.3] 810 1.8 [0.8, 3.6] 353 1.6 [0.8, 3.1] 457 1.9 [0.9, 4.1]
LDL [mg/dL] <70 329 2.8 [1.8, 5.1] 53 2.2 [1.6, 3.6] 276 2.9 [1.9, 5.5] 347 2.4 [0.9, 4.9] 55 2.4 [0.7, 5.0] 292 2.4 [1.0, 4.9]
71–99 809 2.5 [1.6, 4.2] 234 2.2 [1.5, 4.1] 575 2.6 [1.6, 4.2] 860 2.3 [1.0, 4.7] 249 1.9 [1.0, 4.3] 611 2.4 [1.0, 5.0]
100–114 506 2.3 [1.6, 4.0] 204 2.1 [1.3, 3.6] 302 2.5 [1.7, 4.3] 530 2.1 [1.0, 4.8] 214 2.1 [1.0, 4.2] 316 2.1 [1.0, 5.1]
115–154 1168 2.2 [1.4, 3.5] 463 1.9 [1.3, 3.1] 705 2.4 [1.6, 3.7] 1234 2.2 [1.1, 4.6] 485 2.1 [1.0, 4.0] 749 2.5 [1.2, 5.1]
155–189 468 2.1 [1.5, 3.3] 218 1.9 [1.3, 2.9] 250 2.2 [1.6, 3.8] 494 2.5 [1.4, 4.6] 230 2.3 [1.2, 4.1] 264 2.7 [1.5, 5.5]
≥190 159 2.1 [1.3, 3.2] 75 1.8 [1.2, 3.0] 84 2.2 [1.5, 3.4] 166 2.7 [1.2, 5.4] 78 2.3 [1.2, 5.4] 88 3.0 [1.3, 5.4]
Glucose [mg/dL] <100 2133 2.3 [1.5, 3.8] 924 2.0 [1.3, 3.3] 1209 2.5 [1.7, 4.4] 2261 2.2 [1.0, 4.6] 966 2.1 [1.0, 4.1] 1295 2.4 [1.1, 5.0]
100–139.9 1042 2.4 [1.6, 3.7] 324 2.1 [1.4, 3.4] 718 2.5 [1.6, 3.8] 1089 2.3 [1.1, 4.8] 346 2.2 [1.1, 4.8] 743 2.4 [1.1, 4.9]
≥140 256 2.5 [1.7, 4.1] na na 256 2.5 [1.7, 4.1] 272 3.0 [1.4, 6.8] na na 272 3.0 [1.4, 6.8]
eGFR [mL/min/ 1.73 m2] <45 359 3.2 [2.1, 5.3] 70 3.8 [2.6, 6.7] 289 3.0 [2.0, 5.2] 378 3.2 [1.5, 6.3] 77 3.5 [1.9, 6.3] 301 3.0 [1.5, 6.3]
45–60 639 2.7 [1.7, 4.1] 187 2.4 [1.5, 3.6] 452 2.8 [1.8, 4.5] 668 2.5 [1.1, 5.4] 192 2.2 [1.1, 4.4] 476 2.7 [1.2, 6.2]
>60 2421 2.1 [1.4, 3.5] 977 1.9 [1.3, 3.1] 1444 2.3 [1.6, 3.8] 2531 2.2 [1.0, 4.4] 1019 2.0 [1.0, 4.1] 1512 2.3 [1.0, 4.7]
Heart rate [per min] <60 341 2.2 [1.5, 3.6] 126 1.8 [1.2, 2.9] 215 2.6 [1.6, 4.0] 354 1.6 [0.9, 3.6] 131 1.8 [1.0, 3.6] 223 1.5 [0.9, 3.6]
60–80 2374 2.2 [1.5, 3.6] 893 2.0 [1.3, 3.2] 1481 2.3 [1.6, 3.8] 2463 2.3 [1.0, 4.5] 929 2.1 [1.0, 4.0] 1534 2.4 [1.1, 4.9]
>80 768 2.7 [1.7, 4.8] 239 2.4 [1.5, 4.0] 529 2.8 [1.8, 5.1] 801 3.0 [1.4, 6.2] 252 2.7 [1.3, 5.6] 549 3.1 [1.4, 6.3]
Smoking Never 1968 2.3 [1.5, 3.7] 689 1.9 [1.3, 3.1] 1279 2.4 [1.6, 4.1] 2035 2.3 [1.1, 4.5] 710 2.1 [1.0, 3.9] 1325 2.4 [1.1, 4.9]
Past 1196 2.4 [1.5, 3.8] 424 2.0 [1.4, 3.3] 772 2.5 [1.6, 4.0] 1250 2.2 [1.0, 4.8] 450 2.1 [1.0, 4.5] 800 2.3 [1.0, 5.0]
Current 304 2.7 [1.7, 4.5] 140 2.4 [1.4, 3.7] 164 3.0 [1.8, 5.2] 319 3.1 [1.3, 6.2] 147 2.4 [1.1, 5.1] 172 3.4 [1.5, 7.7]
MMSE [points] 28–30 1121 1.9 [1.3, 3.1] 606 1.9 [1.2, 3.0] 515 2.0 [1.4, 3.1] 1153 2.0 [1.0, 4.1] 629 1.9 [1.0, 4.1] 524 2.1 [1.0, 4.1]
24–27 1245 2.3 [1.5, 3.7] 637 2.2 [1.4, 3.6] 608 2.4 [1.6, 4.0] 1302 2.3 [1.1, 4.6] 668 2.3 [1.1, 4.4] 634 2.5 [1.1, 5.1]
20–23 593 2.6 [1.7, 4.3] na na 593 2.6 [1.7, 4.3] 617 2.4 [1.2, 5.2] na na 617 2.4 [1.2, 5.2]
10–19 324 3.0 [2.0, 5.5] na na 324 3.0 [2.0, 5.5] 348 2.5 [1.0, 5.4] na na 348 2.5 [1.0, 5.4]
<10 111 3.3 [2.1, 6.0] na na 111 3.3 [2.1, 6.0] 114 3.7 [1.5, 8.3] na na 114 3.7 [1.5, 8.3]
ADL [points] 5–6 3112 2.2 [1.5, 3.6] 1258 2.0 [1.3, 3.3] 1854 2.3 [1.6, 3.7] 3220 2.2 [1.0, 4.4] 1312 2.1 [1.0, 4.3] 1908 2.2 [1.0, 4.5]
3–4 205 3.2 [2.2, 6.2] na na 205 3.2 [2.2, 6.2] 220 3.4 [1.7, 9.3] na na 220 3.4 [1.7, 9.3]
0–2 165 4.2 [2.6, 7.4] na na 165 4.2 [2.6, 7.4] 178 3.9 [1.9, 9.4] na na 178 3.9 [1.9, 9.4]
  1. a: Excluded are individuals with leukocytosis exceeding 10,000/mm3 or treated with glucocorticoids
  2. b: Only individuals without past or current cancer, type 2 diabetes, cardiovascular disease/myocardial infarction/stroke, and with the MMSE score ≥24 and the ADL score 5–6
  3. c: Individuals who did not meet the definition of successful aging
  4. d: Concentrations of IL–6 and CRP are shown as median [1st quartile, 3rd quartile]
  5. n Number of individuals
  6. na Not applicable