Fig. 4

Expression of cellular protective proteins and proinflammatory cytokines in non-stimulated CD56dim and CD56bright NK cells of the oldest seniors (aged over 85), the old aged under 85 and the young. Data are presented as means ± SEM and concern percentages of CD56dim and CD56bright NK cells expressing the studied proteins (%). The same ^#,*,^,^o symbols over bars denote statistically significant differences between respectively CD56dim or CD56bright NK cells of different age groups. Horizontal lines above paired bars denote differences with statistical significance between CD56dim and CD56bright NK cells of the same age group. a. Expression of SIRT1 (%): ^# p = 0.0004; * p = 0.000008; ^ p = 0.003; ^o p = 0.002. b. Expression of SOD2 (%): ^# p = 0.00003; * p = 0.02; ^ p = 0.00007; ^o p = 0.005. c. Expression of intracellular HSP70 (%): ^# p = 0.0003; * p = 0.000005; ^ p = 0.0002; ^o p = 0.000002. d. Expression of surface HSP70 (%): ^# p = 0.02. e. Expression of TNF (%). f. Expression of IFN-γ (%): ^# p = 0.01