Fig. 1
Exercise reduces rates of T cell proliferation and leads to redistribution of T cell subsets. a Rates of CD4 (left panel) and CD8 (right panel) proliferation before (Pre-Walking) and after exercise (Post-Walking) assessed by Ki-67 expression using flow-cytometry. Percentages of Ki-67 expressing cells within the CD4 and CD8 populations are shown. b Enumeration of CD4 (upper panel) and CD8 (lower panel) T cell differentiation subsets based on CD45RO and CCR7 expression Pre- and Post-Walking. Mean (+/- SEM) numbers (109 cells/L) of naïve T cells (TNaïve), central memory T cells (TCM), effector memory T cells (TEM) and terminally differentiated T cells (TTD) are shown. c Mean (+/- SEM) numbers (109 cells/L) of recent thymic emigrants defined as CD31 + CD4 + TNaïve and the central naïve CD31-CD4+ TNaïve subsets. Statistical significance by Wilcoxon signed rank test is indicated as *p < 0.05, **p < 0.01, ***p < 0.001