Skip to main content

Table 5 Microglial and neuropathic pain-related gene expression

From: Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord

Gene M/Y Microglial Pain Function
ABCA1 1.62 Y Y Transporter of cholesterol and other lipids
AIF1 1.53 Y Y Forms complexes with L-fimbrin in membrane ruffles and phagocytic cups; may modulate actin reorganization, facilitates cell migration and phagocytosis
ANXA3 1.55 Y Y Annexin family member; up-regulated following tissue injury
ATF3 1.73 Y Y Complexes with other transcriptional regulators; up-regulated in response to injury; negative regulator of TLR signaling; suppresses innate immune response
BLNK 1.68 Y   Cytoplasmic linker protein important in B cell development
C1QA 1.61 Y Y Part of C1q complex; initial component of classic pathway
C1QB 1.59 Y Y Part of C1q complex
C1QC 1.52 Y Y Part of C1q complex
C4A 1.98 Y Y Cleaved by C1S; combines with C2 cleavage product forms C4b2b complex
CAMK2B 0.64 Y Y Ca2+/calmodulin-dependent protein kinase
CD163 1.59 Y   M2 state microglial marker (aka, ED2); Alt priming gene
CD37 1.54 Y Y Interacts with dectin; regulates PAMP induced IL6 production; microglial sensome
CD53 1.71 Y Y Contributes to transduction of CD2-generated signals in T cells
CD74 1.85 Y Y Invariant MHCII component; processes receptor bound PAMP’S and DAMP’s for presentation to T cells
CSF3R 1.59 Y Y Binds GCSF, which increases M2 state marker expression, and inhibits pro-inflammatory cytokine expression, while promoting neurotrophic factor expression.
CXCL9 1.68 Y Y Ligand for Cxcr3 receptor, activated by TLR ligands and pro-inflammatory cytokines; appears to regulate T cell migration
Egr2 1.96 Y   Transcription factor; Alt priming gene
EMR1 1.81 Y Y Member of adhesion GPCR receptors; required to activate CD8+ regulatory T cells
FAM105A 2.08 Y Y  
FCER1G 1.74 Y Y High affinity Fc epsilon receptor; binds TREM2; involved in response to apoptotic debris, immune complexes through C1q complex
FCGR2B 2.89 Y Y Fc receptor, IgG, low affinity; binds Cxcl7 (CD32B); inhibitory
FCGR3A 1.52 Y Y Aka CD16a; similar to FCGR2B
FCRLS 2.78 Y   Fc immunoglobulin receptor; part of TGFb1 microglial signature response
GOLM1 1.53 Y   Assists transport of cargo through Golgi apparatus; AD risk gene
IGF1 0.65 Y   Neurotrophic factor; increased by IL4/MCSF; M2 phenotype and Alt priming gene
IGFBP6 1.53 Y Y Binds IGF’s and modulates their growth factor effects
ITGB2 1.73 Y Y CD18; integrin beta chain beta 2; involved in leukocyte adhesion
LGALS3 2.44 Y   Galectin family; inflammatory factor (MAC2); microglial marker; Alt priming gene
PTPRC 1.84 Y Y Protein tyrosine phosphatase; aka CD45; enriched in microglia; opposes microglial activation
PYCARD 1.50 Y Y Mediator of apoptosis and inflammation; adapter for inflammasome assembly
TLR7 1.84 Y Y TLR (nucleotide sensing); signals via MyD88 pathway; can modulate other TLR’s
TMEM173 1.52 Y Y Facilitates innate immune signaling; promotes expression of IFN-alpha and IFN-beta;
TREM2 1.74 Y   Forms signaling complex with TYROBP; M2 state and sensome gene; promotes microglial expansion; up-regulated by IL4; critical for normal phagocytosis
TYROBP 1.82 Y Y Forms signaling complex with TREM2; activates microglia; required for synaptic pruning
  1. The annotated differentially expressed gene set (353) was compared to previously published consensus genes specific for microglia. Those relevant to establishment of neuropathic pain are indicated