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Table 1 Singular Enrichment Analysis results from DAVID v6.7

From: Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice

Gene list

Category

Term

Count

P Value

FDR

Naïve Up

GOTERM_BP_FAT

GO:0006955 ~ immune response

13

1.72E-05

0.000266

GOTERM_CC_FAT

GO:0005576 ~ extracellular region

15

4.64E-05

0.000517

KEGG_PATHWAY

mmu04060:Cytokine-cytokine receptor interaction

8

1.41E-04

0.001418

GOTERM_BP_FAT

GO:0042981 ~ regulation of apoptosis

13

3.17E-04

0.004887

Naïve Down

N/A

N/A

N/A

N/A

 

Memory Up

KEGG_PATHWAY

mmu04060:Cytokine-cytokine receptor interaction

12

1.34E-05

0.000151

GOTERM_MF_FAT

GO:0004866 ~ endopeptidase inhibitor activity

7

9.61E-05

0.001289

INTERPRO

IPR007110:Immunoglobulin-like

13

2.07E-04

0.002886

GOTERM_CC_FAT

GO:0016021 ~ integral to membrane

58

3.68E-04

0.004519

GOTERM_BP_FAT

GO:0032653 ~ regulation of interleukin-10 production

4

6.05E-04

0.00977

GOTERM_BP_FAT

GO:0002684 ~ positive regulation of immune system process

11

8.28E-04

0.01335

GOTERM_BP_FAT

GO:0051249 ~ regulation of lymphocyte activation

9

0.001606

0.025729

GOTERM_BP_FAT

GO:0050871 ~ positive regulation of B cell activation

5

0.00307

0.048641

Memory Down

N/A

N/A

N/A

N/A

N/A

  1. Lists of genes differentially expressed between young and old mice at FDR ≤0.05 in naïve and memory CD4+ T cells were used as input, with all expressed genes in naïve and memory cells used as background. Broad terms such as “signal” and “disulfide bond” were excluded. A FDR of 0.05 was used as a threshold for enriched terms. No terms were significantly enriched in down-regulated gene lists