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Table 1 Singular Enrichment Analysis results from DAVID v6.7

From: Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice

Gene list Category Term Count P Value FDR
Naïve Up GOTERM_BP_FAT GO:0006955 ~ immune response 13 1.72E-05 0.000266
GOTERM_CC_FAT GO:0005576 ~ extracellular region 15 4.64E-05 0.000517
KEGG_PATHWAY mmu04060:Cytokine-cytokine receptor interaction 8 1.41E-04 0.001418
GOTERM_BP_FAT GO:0042981 ~ regulation of apoptosis 13 3.17E-04 0.004887
Naïve Down N/A N/A N/A N/A  
Memory Up KEGG_PATHWAY mmu04060:Cytokine-cytokine receptor interaction 12 1.34E-05 0.000151
GOTERM_MF_FAT GO:0004866 ~ endopeptidase inhibitor activity 7 9.61E-05 0.001289
INTERPRO IPR007110:Immunoglobulin-like 13 2.07E-04 0.002886
GOTERM_CC_FAT GO:0016021 ~ integral to membrane 58 3.68E-04 0.004519
GOTERM_BP_FAT GO:0032653 ~ regulation of interleukin-10 production 4 6.05E-04 0.00977
GOTERM_BP_FAT GO:0002684 ~ positive regulation of immune system process 11 8.28E-04 0.01335
GOTERM_BP_FAT GO:0051249 ~ regulation of lymphocyte activation 9 0.001606 0.025729
GOTERM_BP_FAT GO:0050871 ~ positive regulation of B cell activation 5 0.00307 0.048641
Memory Down N/A N/A N/A N/A N/A
  1. Lists of genes differentially expressed between young and old mice at FDR ≤0.05 in naïve and memory CD4+ T cells were used as input, with all expressed genes in naïve and memory cells used as background. Broad terms such as “signal” and “disulfide bond” were excluded. A FDR of 0.05 was used as a threshold for enriched terms. No terms were significantly enriched in down-regulated gene lists