From: Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice
Enriched in Naïve Young (vs. Naïve Old) Hallmarks | SIZE | FDR | Enriched in Memory Young (vs. Memory Old) Hallmarks | SIZE | FDR |
---|---|---|---|---|---|
MYC_TARGETS_V1 | 155 | 0.001215 | OXIDATIVE_PHOSPHORYLATION | 163 | 0.001571 |
MYC_TARGETS_V2 | 40 | 0.002431 | G2M_CHECKPOINT | 128 | 0.011848 |
OXIDATIVE_PHOSPHORYLATION | 162 | 0.002438 | E2F_TARGETS | 144 | 0.017543 |
DNA_REPAIRa | 119 | 0.056895 | MYC_TARGETS_V1 | 157 | 0.022091 |
ANDROGEN_RESPONSE | 64 | 0.02355 | |||
Enriched in Naïve Young (vs. Naïve Old) | SIZE | FDR | Enriched in Memory Young (vs. Memory Young) GO terms | SIZE | FDR |
REGULATION_OF_GENE_EXPRESSION_EPIGENETIC | 19 | 0.040616 | N/A | N/A | N/A |
RIBONUCLEOPROTEIN_COMPLEXa | 95 | 0.057685 | |||
Enriched in Naïve Old (vs. Naïve Young) | SIZE | FDR | Enriched in Memory Old (vs. Memory Young) Hallmarks | SIZE | FDR |
IL2_STAT5_SIGNALING | 128 | 0 | TNFA_SIGNALING_VIA_NFKB | 118 | 0.00186 |
TNFA_SIGNALING_VIA_NFKB | 112 | 0 | IL2_STAT5_SIGNALING | 142 | 0.002496 |
INTERFERON_GAMMA_RESPONSE | 130 | 0 | INTERFERON_GAMMA_RESPONSE | 135 | 0.010827 |
COMPLEMENT | 92 | 2.19E-04 | KRAS_SIGNALING_UP | 80 | 0.029101 |
IL6_JAK_STAT3_SIGNALING | 44 | 2.74E-04 | IL6_JAK_STAT3_SIGNALING | 52 | 0.035991 |
INFLAMMATORY_RESPONSE | 92 | 7.16E-04 | ALLOGRAFT_REJECTION | 129 | 0.039874 |
KRAS_SIGNALING_UP | 79 | 7.53E-04 | INFLAMMATORY_RESPONSE | 98 | 0.046285 |
ALLOGRAFT_REJECTION | 126 | 0.001159 | |||
APOPTOSIS | 100 | 0.012965 | |||
ESTROGEN_RESPONSE_EARLY | 80 | 0.015578 | |||
EPITHELIAL_MESENCHYMAL_TRANSITION | 53 | 0.030826 | |||
CHOLESTEROL_HOMEOSTASIS | 40 | 0.045692 | |||
Enriched in Naïve Old (vs. Naïve Young) | SIZE | FDR | Enriched in Memory Old (vs. Memory Young) GO Terms | SIZE | FDR |
IMMUNE_RESPONSE | 122 | 0.002943 | N/A | N/A | N/A |
CYTOKINE_ACTIVITY | 26 | 0.014125 | |||
CYTOKINE_BINDING | 25 | 0.014879 | |||
VIRAL_REPRODUCTIVE_PROCESS | 22 | 0.045368 | |||
PROTEIN_TYROSINE_KINASE_ACTIVITY | 21 | 0.045902 | |||
TRANSMEMBRANE_RECEPTOR_ACTIVITY | 70 | 0.046233 | |||
CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY | 24 | 0.051925 | |||
POSITIVE_REGULATION_OF_CELL_PROLIFERATIONa | 59 | 0.055409 |