Table 4 Cis-regulatory analysis of genes differentially expressed (FDR ≤0.05) during aging by oPOSSUM-3
From: Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice
Cell Type | Direction | TFBS | # of Targets | Z-score | F p-value | Cell Type | Direction | TFBS | # of Targets | Z-score | F p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
Naïve | Up | NF-kappaB* | 56 | 6.6 | 0.00197 | Memory | Up | IRF1 | 82 | 15.916 | 4.7098E-08 |
Naïve | Up | Ar* | 6 | 10.673 | 0.01202 | Memory | Up | HOXA5 | 170 | 15.025 | 0.00065615 |
Memory | Up | Ar | 12 | 13.167 | 0.00010069 | ||||||
Memory | Up | HNF1B | 42 | 11.353 | 0.00990832 | ||||||
Memory | Up | PPARG::RXRA | 72 | 7.257 | 0.00070307 | ||||||
Memory | Up | Gata1 | 152 | 6.963 | 0.00028379 | ||||||
Memory | Up | NFKB1* | 45 | 6.94 | 0.00058749 | ||||||
Memory | Up | Foxq1* | 92 | 6.759 | 6.2087E-05 | ||||||
Memory | Up | Foxd3* | 113 | 9.875 | 0.08090959 | ||||||
Cell Type | Direction | TFBS | # of Targets | Z-score | F p-value | Cell Type | Direction | TFBS | # of Targets | Z-score | F p-value |
Naïve | Down | Prrx2 | 46 | 19.911 | 0.00112 | Memory | Down | TP53 | 1 | 12.016 | 0.0043451 |
Naïve | Down | FOXI1 | 39 | 16.131 | 0.004315 | Memory | Down | Gfi | 64 | 11.621 | 0.00210378 |
Naïve | Down | Nobox | 43 | 15.018 | 0.002301 | Memory | Down | Ar | 7 | 9.839 | 6.9823E-05 |
Naïve | Down | NFIL3 | 23 | 14.324 | 0.009441 | Memory | Down | TEAD1 | 38 | 9.762 | 3.2211E-09 |
Naïve | Down | Gfi | 45 | 13.979 | 0.000217 | Memory | Down | TBP | 59 | 9.326 | 4.8641E-08 |
Naïve | Down | Sox17 | 45 | 13.953 | 0.002388 | Memory | Down | FEV | 73 | 9.251 | 7.0307E-06 |
Naïve | Down | FOXO3 | 44 | 13.693 | 0.006281 | Memory | Down | NFIL3 | 37 | 9.063 | 0.00019231 |
Naïve | Down | Foxq1 | 27 | 13.092 | 0.007568 | Memory | Down | Lhx3 | 28 | 8.971 | 0.00107152 |
Naïve | Down | HLF | 23 | 12.977 | 0.000107 | Memory | Down | Pdx1 | 69 | 8.883 | 0.00365595 |
Naïve | Down | Gata1 | 47 | 12.834 | 0.000198 | Memory | Down | FOXF2 | 25 | 8.74 | 8.3946E-05 |
Naïve | Down | Tal1::Gata1 | 24 | 12.074 | 0.001469 | Memory | Down | NR3C1 | 19 | 8.273 | 7.9799E-06 |
Naïve | Down | CEBPA | 41 | 10.428 | 0.004955 | Memory | Down | Stat3 | 53 | 7.515 | 9.2897E-05 |
Naïve | Down | TBP | 35 | 9.593 | 0.004688 | Memory | Down | SPI1 | 74 | 7.368 | 1.3183E-05 |
Naïve | Down | SOX9 | 40 | 9.21 | 0.001014 | Memory | Down | ELF5 | 77 | 7.248 | 4.14E-08 |
Naïve | Down | Myb | 44 | 9.044 | 0.002547 | Memory | Down | Egr1 | 37 | 7.203 | 7.4131E-06 |
Naïve | Down | RREB1 | 7 | 7.524 | 0.004571 | Memory | Down | Prrx2 | 69 | 7.103 | 9.1411E-05 |
Naïve | Down | ELF5 | 51 | 7.382 | 3.47E-05 |