Skip to main content

Advertisement

Table 4 Cis-regulatory analysis of genes differentially expressed (FDR ≤0.05) during aging by oPOSSUM-3

From: Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice

Cell Type Direction TFBS # of Targets Z-score F p-value Cell Type Direction TFBS # of Targets Z-score F p-value
Naïve Up NF-kappaB* 56 6.6 0.00197 Memory Up IRF1 82 15.916 4.7098E-08
Naïve Up Ar* 6 10.673 0.01202 Memory Up HOXA5 170 15.025 0.00065615
Memory Up Ar 12 13.167 0.00010069
Memory Up HNF1B 42 11.353 0.00990832
Memory Up PPARG::RXRA 72 7.257 0.00070307
Memory Up Gata1 152 6.963 0.00028379
Memory Up NFKB1* 45 6.94 0.00058749
Memory Up Foxq1* 92 6.759 6.2087E-05
Memory Up Foxd3* 113 9.875 0.08090959
Cell Type Direction TFBS # of Targets Z-score F p-value Cell Type Direction TFBS # of Targets Z-score F p-value
Naïve Down Prrx2 46 19.911 0.00112 Memory Down TP53 1 12.016 0.0043451
Naïve Down FOXI1 39 16.131 0.004315 Memory Down Gfi 64 11.621 0.00210378
Naïve Down Nobox 43 15.018 0.002301 Memory Down Ar 7 9.839 6.9823E-05
Naïve Down NFIL3 23 14.324 0.009441 Memory Down TEAD1 38 9.762 3.2211E-09
Naïve Down Gfi 45 13.979 0.000217 Memory Down TBP 59 9.326 4.8641E-08
Naïve Down Sox17 45 13.953 0.002388 Memory Down FEV 73 9.251 7.0307E-06
Naïve Down FOXO3 44 13.693 0.006281 Memory Down NFIL3 37 9.063 0.00019231
Naïve Down Foxq1 27 13.092 0.007568 Memory Down Lhx3 28 8.971 0.00107152
Naïve Down HLF 23 12.977 0.000107 Memory Down Pdx1 69 8.883 0.00365595
Naïve Down Gata1 47 12.834 0.000198 Memory Down FOXF2 25 8.74 8.3946E-05
Naïve Down Tal1::Gata1 24 12.074 0.001469 Memory Down NR3C1 19 8.273 7.9799E-06
Naïve Down CEBPA 41 10.428 0.004955 Memory Down Stat3 53 7.515 9.2897E-05
Naïve Down TBP 35 9.593 0.004688 Memory Down SPI1 74 7.368 1.3183E-05
Naïve Down SOX9 40 9.21 0.001014 Memory Down ELF5 77 7.248 4.14E-08
Naïve Down Myb 44 9.044 0.002547 Memory Down Egr1 37 7.203 7.4131E-06
Naïve Down RREB1 7 7.524 0.004571 Memory Down Prrx2 69 7.103 9.1411E-05
Naïve Down ELF5 51 7.382 3.47E-05       
  1. Table shows transcription factor binding sites found to be enriched in +/− 10 kb regions flanking transcription start site of target genes (excluding coding regions). See Methods for explanation of Z-score and Fisher p-value