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Table 5 Comparison with previous mouse and human results

From: Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice

Dataset 1

Dataset 2

Direction

Genes

P-value

Human CD4+

(118)

Mouse Naïve

(119)

Up

Casp1 , Dusp6, Rgs1,

p < 0.021

Human CD4+

(118)

Mouse Naïve

(Mirza et al., 2011) (734)

Up

Acvr2a, Aqp9, Arrdc4, Bcl2l2, Casp1 , Cd86, Fcgr2b, Fgl2, Fndc3b, Il1r2 , Ltb4r1, Rgs12, Lyn

p < 6.225e-05

Human CD4+

(118)

Mouse Memory

(237)

Up

Bcl6, Casp1 , Cyp4v3, Dusp6, Il1r2 , Plcb2,

p < 0.001

Mouse Naïve

(119)

Mouse Naïve

(Mirza et al., 2011) (734)

Up

Abhd4, Adssl1, Bhlhb2, Bmp7, Casp1 , Casp4, Xcl1, Ccl5, Cxcr3, Csprs, Endod1, Esm1, Eomes, Gbp3, Hmgn3, Ier3, Klf9, Lrrk1, Lpxn, Myo1f, Nkg7, Naip2, Ryk, Serpina9, Serpina3g, Zcchc18

p < 1.866e-15

Human CD4+

(181)

Mouse Naïve

(65)

Down

Foxp1

p < 0.387

Human CD4+

(181)

Mouse Naïve

(Mirza et al., 2011) (1382)

Down

Calb2, Epb4.1, Eef1d, Foxp1 , Gpa33, Tgfbr2

p < 0.102

Human CD4+

(181)

Mouse Memory

(107)

Down

l7Rn6, Trat1, Ube2n,

p < 0.047

Mouse Naïve

(65)

Mouse Naïve

(Mirza et al., 2011) (1382)

Down

Actn2, Actn1, Bcl9l, Ecm1, Foxp1 , Mid1,

p < 0.166

  1. Rows performing comparison with data from current study include genes differentially expressed at FDR ≤0.05. Bolded terms were identified in multiple comparisons. Parenthesis indicate total number of genes used for comparison. Note that genes beginning with LOC were removed from gene lists from the current study for these comparisons, as they had been removed from the other studies, and thus the totals are slightly lower than reported in Fig. 1. P-values were calculated using the hypergeometric test