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Table 2 Multiple logistic regression analyses on the association of hsCRP and Alzheimer disease (AD)

From: The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: The HUNT study, Norway

  AD NCa Debut AD 0.4-7 years later NCa Debut AD 7-15 years later NCa
(1) Age ≥60b n = 2150 52 (4) Age ≥ 60 n = 2150 23 (7) Age ≥ 60 n = 2150 29
Model 1c .77 (.47-1.26)   Model 1 .80 (.39-1.67)   Model 1 .84 (.41-1.71)  
Model 2d .75 (.46-1.24)   Model 2 .82 (.39-1.73)   Model 2 .80 (.39-1.64)  
Model 3e .78 (.47-1.32)   Model 3 .86 (.39-1.86)   Model 3 .83 (.39-1.75)  
Model 4f .82 (.49-1.38)   Model 4 .93 (.42-2.04)   Model 4 .83 (.39-1.77)  
hsCRP*Age .93 (.87-.99)   hsCRP*Age .88 (.80-.97)   hsCRP*Age .59 (.70-4.70)  
hsCRP*Sex .90 (.31-2.64)   hsCRP*Sex 1.24 (.27-5.73)   hsCRP*Sex 2.40 (.37-15.71)  
(2) Age 60-70.5b n = 1176 20 (5) Age 60-70.5 n = 1176 6 (8) Age 60-70.5 n = 1176 14
Model 1 1.85 (.89-3.85)   Model 1 4.20 (1.05-16.77)   Model 1 1.31 (.50-3.39)  
Model 2 1.83 (.85-3.93)   Model 2 5.77 (1.32-25.35)   Model 2 1.12 (.41-3.02)  
Model 3 2.34 (1.02-5.35)   Model 3 11.32 (2.01-63.67)   Model 3 1.29 (.44-3.80)  
Model 4 2.37 (1.01-5.58)   Model 4 14.20 (1.80- 112.22)   Model 4 1.29 (.42-3.96)  
hsCRP*Age 1.10 (.82-1.46)   hsCRP*Age 1.07 (.59-1.95)   hsCRP*Age 1.58 (1.03-2.42)  
hsCRP*Sex 2.40 (.37-15.71)   hsCRP*Sex 9.02 (.15-552.04)   hsCRP*Sex 1.67 (.48-5.78)  
(3) Age 70.6-94b n = 974 32 (6) Age 70.6-94 n = 974 17 (9) Age 70.6-94 n = 974 15
Model 1 .36 (.18-.74)   Model 1 .35 (.13-.93)   Model 1 .48 (.16-1.46)  
Model 2 .36 (.18-.73)   Model 2 .33 (.13-.89)   Model 2 .50 (.16-1.5)  
Model 3 .35 (.17-.74)   Model 3 .31 (.11-.84)   Model 3 .53 (.17-1.68)  
Model 4 .39 (.19-.84)   Model 4 .34 (.12-.96)   Model 4 .54 (.16-1.81)  
hsCRP*Age .93 (.77-1.13)   hsCRP*Age .77 (.58-1.03)   hsCRP*Age 1.07 (.82-1.39)  
hsCRP*Sex .65 (.14-2.99)   hsCRP*Sex .64 (.08-4.97)   hsCRP*Sex 1.54 (.08-30.13)  
  1. Results of the total sample (age ≥ 60) are shown in the upper left section (1), in age group 60-70.5 in middle left section (2) and in age group >70.6 in lower left section (3). Section 4-9 show analyses according to time from baseline (HUNT 2) to debut of AD, in different age groups
  2. aNumber of dementia cases
  3. bAge when examined in HUNT 2
  4. cModel 1: log transformed high specificity C-reactive protein (hsCRP)
  5. dModel 2: hsCRP, age, sex, education
  6. eModel 3: hsCRP, age, sex, education, cholesterol, triglycerides, non-fasting blood glucose, creatinine, body mass index, pulse
  7. fModel 4: SBP, age, sex, education, cholesterol, triglycerides, non-fasting blood glucose, glomerular filtration rate, body mass index, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status