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Table 2 Multiple logistic regression analyses on the association of hsCRP and Alzheimer disease (AD)

From: The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: The HUNT study, Norway

 

AD

NCa

Debut AD 0.4-7 years later

NCa

Debut AD 7-15 years later

NCa

(1) Age ≥60b

n = 2150

52

(4) Age ≥ 60

n = 2150

23

(7) Age ≥ 60

n = 2150

29

Model 1c

.77 (.47-1.26)

 

Model 1

.80 (.39-1.67)

 

Model 1

.84 (.41-1.71)

 

Model 2d

.75 (.46-1.24)

 

Model 2

.82 (.39-1.73)

 

Model 2

.80 (.39-1.64)

 

Model 3e

.78 (.47-1.32)

 

Model 3

.86 (.39-1.86)

 

Model 3

.83 (.39-1.75)

 

Model 4f

.82 (.49-1.38)

 

Model 4

.93 (.42-2.04)

 

Model 4

.83 (.39-1.77)

 

hsCRP*Age

.93 (.87-.99)

 

hsCRP*Age

.88 (.80-.97)

 

hsCRP*Age

.59 (.70-4.70)

 

hsCRP*Sex

.90 (.31-2.64)

 

hsCRP*Sex

1.24 (.27-5.73)

 

hsCRP*Sex

2.40 (.37-15.71)

 

(2) Age 60-70.5b

n = 1176

20

(5) Age 60-70.5

n = 1176

6

(8) Age 60-70.5

n = 1176

14

Model 1

1.85 (.89-3.85)

 

Model 1

4.20 (1.05-16.77)

 

Model 1

1.31 (.50-3.39)

 

Model 2

1.83 (.85-3.93)

 

Model 2

5.77 (1.32-25.35)

 

Model 2

1.12 (.41-3.02)

 

Model 3

2.34 (1.02-5.35)

 

Model 3

11.32 (2.01-63.67)

 

Model 3

1.29 (.44-3.80)

 

Model 4

2.37 (1.01-5.58)

 

Model 4

14.20 (1.80- 112.22)

 

Model 4

1.29 (.42-3.96)

 

hsCRP*Age

1.10 (.82-1.46)

 

hsCRP*Age

1.07 (.59-1.95)

 

hsCRP*Age

1.58 (1.03-2.42)

 

hsCRP*Sex

2.40 (.37-15.71)

 

hsCRP*Sex

9.02 (.15-552.04)

 

hsCRP*Sex

1.67 (.48-5.78)

 

(3) Age 70.6-94b

n = 974

32

(6) Age 70.6-94

n = 974

17

(9) Age 70.6-94

n = 974

15

Model 1

.36 (.18-.74)

 

Model 1

.35 (.13-.93)

 

Model 1

.48 (.16-1.46)

 

Model 2

.36 (.18-.73)

 

Model 2

.33 (.13-.89)

 

Model 2

.50 (.16-1.5)

 

Model 3

.35 (.17-.74)

 

Model 3

.31 (.11-.84)

 

Model 3

.53 (.17-1.68)

 

Model 4

.39 (.19-.84)

 

Model 4

.34 (.12-.96)

 

Model 4

.54 (.16-1.81)

 

hsCRP*Age

.93 (.77-1.13)

 

hsCRP*Age

.77 (.58-1.03)

 

hsCRP*Age

1.07 (.82-1.39)

 

hsCRP*Sex

.65 (.14-2.99)

 

hsCRP*Sex

.64 (.08-4.97)

 

hsCRP*Sex

1.54 (.08-30.13)

 
  1. Results of the total sample (age ≥ 60) are shown in the upper left section (1), in age group 60-70.5 in middle left section (2) and in age group >70.6 in lower left section (3). Section 4-9 show analyses according to time from baseline (HUNT 2) to debut of AD, in different age groups
  2. aNumber of dementia cases
  3. bAge when examined in HUNT 2
  4. cModel 1: log transformed high specificity C-reactive protein (hsCRP)
  5. dModel 2: hsCRP, age, sex, education
  6. eModel 3: hsCRP, age, sex, education, cholesterol, triglycerides, non-fasting blood glucose, creatinine, body mass index, pulse
  7. fModel 4: SBP, age, sex, education, cholesterol, triglycerides, non-fasting blood glucose, glomerular filtration rate, body mass index, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status
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Immunity & Ageing

ISSN: 1742-4933

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